Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1965 Nov 30;122(6):1151–1160. doi: 10.1084/jem.122.6.1151

STUDIES OF A MYXOVIRUS RECOVERED FROM PATIENTS WITH INFECTIOUS HEPATITIS

II. FINE STRUCTURE AND ELECTRON MICROSCOPIC DEMONSTRATION OF INTRACYTOPLASMIC INTERNAL COMPONENT AND VIRAL FILAMENT FORMATION

Philip H Prose 1, Samuel D Balk 1, Harvey Liebhaber 1, Saul Krugman 1
PMCID: PMC2138103  PMID: 4289292

Abstract

WB virus has been shown to have a fine structure which is characteristic of members of the mumps-NDV-parainfluenza group of viruses. Viral internal component has been demonstrated within the cytoplasm of infected cells. The incorporation of internal component into virus filaments at the cell surface has also been demonstrated. The evidence presented suggests that virus filament formation occurs by a process of invagination of the cell membrane about the coiled strands of internal component lying beneath the membrane.

Full Text

The Full Text of this article is available as a PDF (2.1 MB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHOPPIN P. W., STOECKENIUS W. THE MORPHOLOGY OF SV5 VIRUS. Virology. 1964 Jun;23:195–202. doi: 10.1016/0042-6822(64)90282-x. [DOI] [PubMed] [Google Scholar]
  2. LIEBHABER H., KRUGMAN S., GILES J. P., MCGREGOR D. M. RECOVERY OF CYTOPATHIC AGENTS FROM PATIENTS WITH INFECTIOUS HEPATITIS: ISOLATION AND PROPAGATION IN CULTURES OF HUMAN DIPLOID LUNG FIBROBLASTS (WI-38). Virology. 1964 Sep;24:109–113. doi: 10.1016/0042-6822(64)90155-2. [DOI] [PubMed] [Google Scholar]
  3. Liebhaber H., Krugman S., McGregor D., Giles J. P. Studies of a myxovirus recovered from patients with infectious hepatitis. J Exp Med. 1965 Dec 1;122(6):1135–1150. doi: 10.1084/jem.122.6.1135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. MORGAN C., ROSE H. M., MOORE D. H. Structure and development of viruses observed in the electron microscope. III. Influenza virus. J Exp Med. 1956 Aug 1;104(2):171–182. doi: 10.1084/jem.104.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. REDA I. M., ROTT R., SCHAEFER W. FLUORESCENT ANTIBODY STUDIES WITH NDV-INFECTED CELL SYSTEMS. Virology. 1964 Mar;22:422–425. doi: 10.1016/0042-6822(64)90033-9. [DOI] [PubMed] [Google Scholar]
  6. WATSON B. K., COONS A. H. Studies of influenza virus infection in the chick embryo using fluorescent antibody. J Exp Med. 1954 May 1;99(5):419–428. doi: 10.1084/jem.99.5.419. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES