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. 1965 Nov 30;122(6):1135–1150. doi: 10.1084/jem.122.6.1135

STUDIES OF A MYXOVIRUS RECOVERED FROM PATIENTS WITH INFECTIOUS HEPATITIS

I. ISOLATION AND CHARACTERIZATION

Harvey Liebhaber 1, Saul Krugman 1, Dorothy McGregor 1, Joan P Giles 1
PMCID: PMC2138105  PMID: 4285254

Abstract

A virus has been isolated from the serum and urine of patients with infectious hepatitis. This virus is a member of the parinfluenza group. It is serologically distinct from the known members of the group, but apparently is antigenically related to the simian type-2 parainfluenza viruses. A causal relationship between WB virus and infectious hepatitis has not been established.

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Selected References

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  1. DAVIS E. V. Isolation of viruses from children with infectious hepatitis. Science. 1961 Jun 30;133(3470):2059–2061. doi: 10.1126/science.133.3470.2059. [DOI] [PubMed] [Google Scholar]
  2. DULBECCO R., VOGT M. Plaque formation and isolation of pure lines with poliomyelitis viruses. J Exp Med. 1954 Feb;99(2):167–182. doi: 10.1084/jem.99.2.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. EAGLE H. Amino acid metabolism in mammalian cell cultures. Science. 1959 Aug 21;130(3373):432–437. doi: 10.1126/science.130.3373.432. [DOI] [PubMed] [Google Scholar]
  4. GILES J. P., LIEBHABER H., KRUGMAN S., LATTIMER C. EARLY VIREMIA AND VIRURIA IN INFECTIOUS HEPATITIS. Virology. 1964 Sep;24:107–108. doi: 10.1016/0042-6822(64)90154-0. [DOI] [PubMed] [Google Scholar]
  5. HENLE W., HARRIS S., HENLE G., HARRIS T. N., DRAKE M. E., MANGOLD F., STOKES J., Jr Studies on the agent of infectious hepatitis; propagation of the agent in tissue culture and in the embryonated hen's egg. J Exp Med. 1950 Sep;92(3):271–281. doi: 10.1084/jem.92.3.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HSIUNG G. D., ISACSON P., McCOLLUM R. W. Studies of a myxovirus isolated from human blood. I. Isolation and properties. J Immunol. 1962 Mar;88:284–290. [PubMed] [Google Scholar]
  7. JENSEN K. E. Diagnosis of influenza by serologic methods. Am Rev Respir Dis. 1961 Feb;83(2):120–124. doi: 10.1164/arrd.1961.83.2P2.120. [DOI] [PubMed] [Google Scholar]
  8. KRUGMAN S., WARD R., GILES J. P., BODANSKY O., JACOBS A. M. Infectious hepatitis: detection of virus during the incubation period and in clinically inapparent infection. N Engl J Med. 1959 Oct 8;261:729–734. doi: 10.1056/NEJM195910082611501. [DOI] [PubMed] [Google Scholar]
  9. KRUGMAN S., WARD R., GILES J. P. The natural history of infectious hepatitis. Am J Med. 1962 May;32:717–728. doi: 10.1016/0002-9343(62)90161-4. [DOI] [PubMed] [Google Scholar]
  10. LEPINE P., CHANY C., DROZ B., ROBBE-FOSSAT F. Cytopathogenic effect of two newly recognized myxovirus strains: mechanism of syncytial formation. Ann N Y Acad Sci. 1959 Jul 21;81:62–72. doi: 10.1111/j.1749-6632.1959.tb49295.x. [DOI] [PubMed] [Google Scholar]
  11. LIEBHABER H., KRUGMAN S., GILES J. P., MCGREGOR D. M. RECOVERY OF CYTOPATHIC AGENTS FROM PATIENTS WITH INFECTIOUS HEPATITIS: ISOLATION AND PROPAGATION IN CULTURES OF HUMAN DIPLOID LUNG FIBROBLASTS (WI-38). Virology. 1964 Sep;24:109–113. doi: 10.1016/0042-6822(64)90155-2. [DOI] [PubMed] [Google Scholar]
  12. MALHERBE H., HARWIN R. Seven viruses isolated from the vervet monkey. Br J Exp Pathol. 1957 Oct;38(5):539–541. [PMC free article] [PubMed] [Google Scholar]
  13. O'MALLEY J. P., MEYER H. M., Jr, SMADEL J. E. Antibody in hepatitis patients against a newly isolated virus. Proc Soc Exp Biol Med. 1961 Oct;108:200–205. doi: 10.3181/00379727-108-26891. [DOI] [PubMed] [Google Scholar]
  14. Prose P. H., Balk S. D., Liebhaber H., Krugman S. Studies of a myxovirus recovered from patients with infectious hepatitis. II. Fine structure and electron microscopic demonstration of intracytoplasmic internal component and viral filament formation. J Exp Med. 1965 Dec 1;122(6):1151–1160. doi: 10.1084/jem.122.6.1151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. RIGHTSEL W. A., KELTSCH R. A., TEKUSHAN F. M., MCLEAN I. W., Jr Tissue-culture cultivation of cytopathogenic agents from patients with clinical hepatitis. Science. 1956 Aug 3;124(3214):226–228. doi: 10.1126/science.124.3214.226. [DOI] [PubMed] [Google Scholar]
  16. TAYLOR A. R., RIGHTSEL W. A., BOGGS J. D., McLEAN I. W., Jr Tissue culture of hepatitis virus. Am J Med. 1962 May;32:679–703. doi: 10.1016/0002-9343(62)90159-6. [DOI] [PubMed] [Google Scholar]
  17. TYRRELL D. A., CHANOCK R. M. Rhinoviruses: a description. Science. 1963 Jul 12;141(3576):152–153. doi: 10.1126/science.141.3576.152. [DOI] [PubMed] [Google Scholar]
  18. WARD R., KRUGMAN S., GILES J. P., JACOBS A. M., BODANSKY O. Infectious hepatitis; studies of its natural history and prevention. N Engl J Med. 1958 Feb 27;258(9):407–416. doi: 10.1056/NEJM195802272580901. [DOI] [PubMed] [Google Scholar]

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