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. 1965 Nov 30;122(6):1103–1123. doi: 10.1084/jem.122.6.1103

ROLE OF THE THYMUS IN TOLERANCE

I. TOLERANCE TO BOVINE GAMMA GLOBULIN IN THYMECTOMIZED, IRRADIATED RATS GRAFTED WITH THYMUS FROM TOLERANT DONORS

Katarina Isaković 1, Stanley B Smith 1, Byron H Waksman 1
PMCID: PMC2138106  PMID: 4159035

Abstract

Rats thymectomized and irradiated as adults were restored to immunologic reactivity by grafts of normal adult rat thymus and bone marrow. Reactivity of the delayed (cellular) type and formation of mercaptoethanol-sensitive (MES) and mercaptoethanol-resistant (MER) antibody returned within 3 weeks, while Arthus reactivity remained subnormal till 9 weeks after irradiation and grafting. When the thymus donor was tolerant to BGG, the recipient showed specific non-reactivity to this antigen 3 weeks and, to a much lesser extent, 6 weeks after grafting. This non-reactivity affected delayed responses and MER antibody. No effect was noted on Arthus reactivity and a slight effect on MES antibody. Controls showed that the non-reactivity was not due to transfer of free antigen at the time of grafting. It was concluded that different source organs are responsible for different immune functions and that specific immunologic tolerance may be induced within such an organ as the thymus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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