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. 1965 Oct 31;122(5):905–921. doi: 10.1084/jem.122.5.905

INCREASED VASCULAR PERMEABILITY INDUCED BY HUMAN PLASMIN

Oscar D Ratnoff 1
PMCID: PMC2138110  PMID: 19867295

Abstract

Preparations of plasminogen, soluble in aqueous media, increased vascular permeability in guinea pig skin when activated by streptokinase or urokinase. The permeability-enhancing effect was inhibited by soybean trypsin inhibitor but not by triprolidine. Permeability-enhancing activity evolved when plasmin was incubated with fractions of plasma rich in prokinin. The experiments described suggest that plasmin exerts its permeability-increasing effect through the elaboration of kinins.

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Selected References

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