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. 1966 Jan 31;123(2):347–364. doi: 10.1084/jem.123.2.347

ELEVATED γ-GLOBULIN AND INCREASED ANTIBODY PRODUCTION IN MICE INFECTED WITH LACTIC DEHYDROGENASE VIRUS

Abner Louis Notkins 1, Stephan E Mergenhagen 1, Anthony A Rizzo 1, Christina Scheele 1, Thomas A Waldmann 1
PMCID: PMC2138136  PMID: 4159522

Abstract

Infection of mice with the lactic dehydrogenase virus (LDV) resulted in an elevated level of γ-globulin. Histologic examination of the spleen and lymph nodes revealed that the number of germinal centers was greatly increased. Immunization with human γ-globulin showed that the capacity of the virus-infected animal to produce anti-human γ-globulin was greatly enhanced and that the virus acted as an adjuvant. From these experiments it is concluded that a virus infection (LDV) can affect the immunologic response of the host to a heterologous antigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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