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. 1966 Oct 1;124(4):773–785. doi: 10.1084/jem.124.4.773

DEFICIENCY OF THE SIXTH COMPONENT OF COMPLEMENT IN RABBITS WITH AN INHERITED COMPLEMENT DEFECT

Klaus Rother 1, Ursula Rother 1, Hans J Müller-Eberhard 1, Ulf R Nilsson 1
PMCID: PMC2138255  PMID: 5922290

Abstract

A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-deficient animals, an antibody was obtained which specifically inhibited the hemolytic activity of C'6. The data suggest that C'6-deficient serum either lacks the C'6 molecule or contains it in a chemically modified and inactive form.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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