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. 1967 Jun 1;125(6):983–1000. doi: 10.1084/jem.125.6.983

ON THE NATURE OF TRANSPLANTATION IMMUNITY IN THE ADENOVIRUS TUMOR SYSTEM

Leonard D Berman 1
PMCID: PMC2138275  PMID: 6025323

Abstract

The existence of a virus-induced, virus-specific transplantation, antigen in adenovirus 12-induced CBA mouse tumors was demonstrated. The antigen is virus-specific, but not related to structural virion or T antigens. It is a weak antigen, and required immunization with whole, infectious adenovirus 12 to produce considerable immunity. Comparable immunity could not be achieved with homologous cellular or subcellular materials, but some indication of enhancement was produced with low tumor dose. Immunization required at least 2 wk and was mediated by immune lymphoid cells. Serum of immunized animals showed no demonstrable cytotoxicity or enhancement. Animals immunized with virus and Freund's adjuvant showed diminished transplantation immunity, although these animals were actively immunized against adenovirus type 12 structural virion antigens.

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Selected References

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  1. ALLISON A. C. RELATIONSHIP OF CELLULAR AND HUMORAL IMMUNITY IN VIRUS CARCINOGENESIS. Life Sci. 1964 Dec;3:1415–1422. doi: 10.1016/0024-3205(64)90083-9. [DOI] [PubMed] [Google Scholar]
  2. BERMAN L. D., ROWE W. P. A STUDY OF THE ANTIGENS INVOLVED IN ADENOVIRUS 12 TUMORIGENESIS BY IMMUNODIFFUSION TECHNIQUES. J Exp Med. 1965 Jun 1;121:955–967. doi: 10.1084/jem.121.6.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BLACK P. H., ROWE W. P. VIRAL STUDIES OF SV40 TUMORIGENESIS IN HAMSTERS. J Natl Cancer Inst. 1964 Jan;32:253–265. [PubMed] [Google Scholar]
  4. Babos P. The ribonucleic acid content of tobacco leaves infected with tobacco mosaic virus. Virology. 1966 Feb;28(2):282–289. doi: 10.1016/0042-6822(66)90152-8. [DOI] [PubMed] [Google Scholar]
  5. DEICHMAN G. I., KLUCHAREVA T. E. PREVENTION OF TUMOUR INDUCTION IN SV 40-INFECTED HAMSTERS. Nature. 1964 Jun 13;202:1126–1128. doi: 10.1038/2021126b0. [DOI] [PubMed] [Google Scholar]
  6. EDDY B. E., GRUBBS G. E., YOUNG R. D. TUMOR IMMUNITY IN HAMSTERS INFECTED WITH ADENOVIRUS TYPE 12 OR SIMIAN VIRUS 40. Proc Soc Exp Biol Med. 1964 Nov;117:575–579. doi: 10.3181/00379727-117-29642. [DOI] [PubMed] [Google Scholar]
  7. GOLDNER H., GIRARDI A. J., HILLEMAN M. R. ATTEMPTS TO INTERRUPT VIRUS TUMORIGENESIS BY IMMUNIZATION USING HOMOLOGOUS "BJORKLUND-TYPE" ANTIGEN. Proc Soc Exp Biol Med. 1963 Nov;114:456–467. doi: 10.3181/00379727-114-28704. [DOI] [PubMed] [Google Scholar]
  8. Goldner H., Girardi A. J., Hilleman M. R. Enhancement in hamsters of virus oncogenesis attending vaccination procedures. Virology. 1965 Oct;27(2):225–227. doi: 10.1016/0042-6822(65)90164-9. [DOI] [PubMed] [Google Scholar]
  9. HABEL K. Immunological determinants of polyoma virus oncogenesis. J Exp Med. 1962 Jan 1;115:181–193. doi: 10.1084/jem.115.1.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HABEL K. Resistance of polyoma virus immune animals to transplanted polyoma tumors. Proc Soc Exp Biol Med. 1961 Apr;106:722–725. doi: 10.3181/00379727-106-26453. [DOI] [PubMed] [Google Scholar]
  11. HUEBNER R. J., PEREIRA H. G., ALLISON A. C., HOLLINSHEAD A. C., TURNER H. C. PRODUCTION OF TYPE-SPECIFIC C ANTIGEN IN VIRUS-FREE HAMSTER TUMOR CELLS INDUCED BY ADENOVIRUS TYPE 12. Proc Natl Acad Sci U S A. 1964 Mar;51:432–439. doi: 10.1073/pnas.51.3.432. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HUEBNER R. J., ROWE W. P., TURNER H. C., LANE W. T. SPECIFIC ADENOVIRUS COMPLEMENT-FIXING ANTIGENS IN VIRUS-FREE HAMSTER AND RAT TUMORS. Proc Natl Acad Sci U S A. 1963 Aug;50:379–389. doi: 10.1073/pnas.50.2.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jonsson N. Studies on the occurrence of common specific transplantation antigens in Rous tumors of various mammalian species. Acta Pathol Microbiol Scand. 1966;67(3):339–353. doi: 10.1111/apm.1966.67.3.339. [DOI] [PubMed] [Google Scholar]
  14. KLEMPERER H. G., PEREIRA H. G. Study of adenovirus antigens fractionated by chromatography on DEAE-cellulose. Virology. 1959 Dec;9:536–545. doi: 10.1016/0042-6822(59)90147-3. [DOI] [PubMed] [Google Scholar]
  15. KOCH M. A., SABIN A. B. Specificity of virus-induced resistance to transplantation of polyoma and SV 40 tumors in adult hamsters. Proc Soc Exp Biol Med. 1963 May;113:4–12. doi: 10.3181/00379727-113-28260. [DOI] [PubMed] [Google Scholar]
  16. Kidd J. G., Beard J. W., Rous P. SEROLOGICAL REACTIONS WITH A VIRUS CAUSING RABBIT PAPILLOMAS WHICH BECOME CANCEROUS : I. TESTS OF THE BLOOD OF ANIMALS CARRYING THE PAPILLOMA. J Exp Med. 1936 Jun 30;64(1):63–77. doi: 10.1084/jem.64.1.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. MOLLER G. Studies on the mechanism of immunological enhancement of tumor homografts. I. Specificity of immunological enhancement. J Natl Cancer Inst. 1963 Jun;30:1153–1175. [PubMed] [Google Scholar]
  18. PEREIRA H. G., PEREIRA M. S., LAW V. G. ANTIGENIC VARIANTS OF INFLUENZA A2 VIRUS. Bull World Health Organ. 1964;31:129–132. [PMC free article] [PubMed] [Google Scholar]
  19. POPE J. H., ROWE W. P. IMMUNOFLUORESCENT STUDIES OF ADENOVIRUS 12 TUMORS AND OF CELLS TRANSFORMED OR INFECTED BY ADENOVIRUSES. J Exp Med. 1964 Oct 1;120:577–588. doi: 10.1084/jem.120.4.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. SABIN A. B., KOCH M. A. SOURCE OF GENETIC INFORMATION FOR SPECIFIC COMPLEMENT-FIXING ANTIGENS IN SV40 VIRUS-INDUCED TUMORS. Proc Natl Acad Sci U S A. 1964 Nov;52:1131–1138. doi: 10.1073/pnas.52.5.1131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. SJOEGEN H. O. STUDIES ON SPECIFIC TRANSPLANTATION RESISTANCE TO POLYOMA-VIRUS-INDUCED TUMORS. III. TRANSPLANTATION RESISTANCE TO GENETICALLY COMPATIBLE POLYOMA TUMORS INDUCED BY POLYOMA TUMOR HOMOGRAFTS. J Natl Cancer Inst. 1964 Mar;32:645–659. [PubMed] [Google Scholar]
  22. SJOEGREN H. O., JONSSON N. RESISTANCE AGAINST ISOTRANSPLANTATION OF MOUSE TUMORS INDUCED BY ROUS SARCOMA VIRUS. Exp Cell Res. 1963 Dec;32:618–621. doi: 10.1016/0014-4827(63)90205-2. [DOI] [PubMed] [Google Scholar]
  23. Schild G. C., Potter C. W., Oxford J. S. Inhibition of tumour formation with adenovirus 12 tumour cells in hamsters immunized with various adenoviruses. Nature. 1967 Feb 4;213(5075):519–520. doi: 10.1038/213519a0. [DOI] [PubMed] [Google Scholar]
  24. Sjögren H. O., Minowada J., Ankerst J. Specific transplantation antigens of mouse sarcomas induced by adenovirus type 12. J Exp Med. 1967 Apr 1;125(4):689–701. doi: 10.1084/jem.125.4.689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Trentin J. J., Bryan E. Virus-induced transplantation immunity to human adenovirus type 12 tumors of the hamster and mouse. Proc Soc Exp Biol Med. 1966 Apr;121(4):1216–1219. doi: 10.3181/00379727-121-31009. [DOI] [PubMed] [Google Scholar]

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