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. 1967 Feb 28;125(3):501–510. doi: 10.1084/jem.125.3.501

THE EFFECT OF 5-HYDROXYTRYPTAMINE ON THE COTTON PELLET LOCAL INFLAMMATORY RESPONSE IN THE RAT

Joseph R Bianchine 1, Norman R Eade 1
PMCID: PMC2138287  PMID: 5297527

Abstract

The cotton pellet technique was used to evaluate the effect of 5-HT and certain related compounds on granuloma formation in the rat. 5-HT (10 mg/kg) significantly decreased granuloma formation, significantly increased adrenal weight, and significantly decreased thymus weight in normal rats, and significantly decreased granuloma formation and thymus weight in sham-operated rats. On the other hand, 5-HT (10 mg/kg) significantly increased granuloma weight in adrenalectomized rats. Methysergide (1 mg/kg) blocked the inhibitory effect of 5-HT on granuloma formation as well as the changes in weight of adrenal and thymus glands. 5-HIAA (11 mg/kg) and 5-HTP (13 mg/kg) failed to alter granuloma formation.

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Selected References

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