Abstract
A mouse-adapted Jap. 305 strain of influenza A2 virus was found to be much more readily transmitted from one mouse to another than the NWS strain of influenza A0 virus although the two viruses were equally pathogenic for mice as judged by pulmonary virus titers and lung lesions. The survival of artificially created aerosols of virus and the quantity of airborne virus required to initiate infection in mice were identical for the two viruses. The difference in transmissibility was associated with the recovery of infectious airborne virus in the environment of mice infected with the Jap. 305 strain during the period of their maximum infectiousness, but not in the environment of mice infected with the NWS strain.
Full Text
The Full Text of this article is available as a PDF (468.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CHOPPIN P. W., TAMM I. Two kinds of particles with contrasting properties in influenza A virus strains from the 1957 pandemic. Virology. 1959 Aug;8:539–542. doi: 10.1016/0042-6822(59)90059-5. [DOI] [PubMed] [Google Scholar]
- COWN W. B., KETHLEY T. W., FINCHER E. L. The critical-orifice liquid impinger as a sampler for bacterial aerosols. Appl Microbiol. 1957 Mar;5(2):119–124. doi: 10.1128/am.5.2.119-124.1957. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eaton M. D. Transmission of Epidemic Influenza Virus in Mice by Contact. J Bacteriol. 1940 Mar;39(3):229–241. doi: 10.1128/jb.39.3.229-241.1940. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GINSBERG H. S. Comparison of quantity of egg and mouse-adapted influenza viruses required to infect each host. Proc Soc Exp Biol Med. 1953 Oct;84(1):249–252. doi: 10.3181/00379727-84-20606. [DOI] [PubMed] [Google Scholar]
- SCHULMAN J. L., KILBOURNE E. D. Airborne transmission of influenza virus infection in mice. Nature. 1962 Sep 15;195:1129–1130. doi: 10.1038/1951129a0. [DOI] [PubMed] [Google Scholar]
- SCHULMAN J. L., KILBOURNE E. D. EXPERIMENTAL TRANSMISSION OF INFLUENZA VIRUS INFECTION IN MICE. I. THE PERIOD OF TRANSMISSIBILITY. J Exp Med. 1963 Aug 1;118:257–266. doi: 10.1084/jem.118.2.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHULMAN J. L., KILBOURNE E. D. EXPERIMENTAL TRANSMISSION OF INFLUENZA VIRUS INFECTION IN MICE. II. SOME FACTORS AFFECTING THE INCIDENCE OF TRANSMITTED INFECTION. J Exp Med. 1963 Aug 1;118:267–275. doi: 10.1084/jem.118.2.267. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHULMAN J. L., KILBOURNE E. D. Induction of viral interference in mice by aerosols of inactivated influenza virus. Proc Soc Exp Biol Med. 1963 Jun;113:431–435. doi: 10.3181/00379727-113-28387. [DOI] [PubMed] [Google Scholar]
- SETO J. T., HICKEY B. J., RASMUSSEN A. F., Jr Some biological characteristics of Asian influenza isolates. Proc Soc Exp Biol Med. 1959 Apr;100(4):672–676. doi: 10.3181/00379727-100-24740. [DOI] [PubMed] [Google Scholar]
- Schulman J. L. Experimental transmission of influenza virus infection in mice. 3. Differing effects of immunity induced by infection and by inactivated influenza virus vaccine on transmission of infection. J Exp Med. 1967 Mar 1;125(3):467–478. doi: 10.1084/jem.125.3.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WOLFE E. K., Jr Quantitative characterization of aerosols. Bacteriol Rev. 1961 Sep;25:194–202. doi: 10.1128/br.25.3.194-202.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]