Abstract
The preceding studies have established the following points: Intrathymic labeling of thymic lymphocytes provides an adequate marker system to detect the migration of thymus cells to peripheral lymphoid sites. In the newborn, this comprises a major portion of the total lymphocyte population in lymph nodes and spleen. In the adult, this migration is limited to specific portions of lymph nodes and spleen, i.e., those portions which serve the recirculating pool of small lymphocytes. Kinetic studies of labeling within the adult thymus indicate that large cells give rise to medium and small cells, which then migrate to the specific sites noted above. In the newborn, the kinetic pattern is similar to that of adults, with the single distinction that large cells also migrate, accelerating the tempo of migration in these hosts. The long-term fate and function of thymus cell migrants has not yet been determined.
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Selected References
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- AUERBACH R. Experimental analysis of the origin of cell types in the development of the mouse thymus. Dev Biol. 1961 Jun;3:336–354. doi: 10.1016/0012-1606(61)90051-3. [DOI] [PubMed] [Google Scholar]
- BURNET M. Role of the thymus and related organs in immunity. Br Med J. 1962 Sep 29;2(5308):807–811. doi: 10.1136/bmj.2.5308.807. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davies A. J., Leuchars E., Wallis V., Koller P. C. The mitotic response of thymus-derived cells to antigenic stimulus. Transplantation. 1966 Jul;4(4):438–451. doi: 10.1097/00007890-196607000-00008. [DOI] [PubMed] [Google Scholar]
- GOWANS J. L., KNIGHT E. J. THE ROUTE OF RE-CIRCULATION OF LYMPHOCYTES IN THE RAT. Proc R Soc Lond B Biol Sci. 1964 Jan 14;159:257–282. doi: 10.1098/rspb.1964.0001. [DOI] [PubMed] [Google Scholar]
- GOWANS J. L., McGREGOR D. D., COWEN D. M. Initiation of immune responses by small lymphocytes. Nature. 1962 Nov 17;196:651–655. doi: 10.1038/196651a0. [DOI] [PubMed] [Google Scholar]
- Koldovsky O., Sunshine P., Kretchmer N. Cellular migration of intestinal epithelia in suckling and weaned rats. Nature. 1966 Dec 17;212(5068):1389–1390. doi: 10.1038/2121389a0. [DOI] [PubMed] [Google Scholar]
- MARTINEZ C., KERSEY J., PAPERMASTER B. W., GOOD R. A. Skin homograft survival in thymectomized mice. Proc Soc Exp Biol Med. 1962 Jan;109:193–196. doi: 10.3181/00379727-109-27149. [DOI] [PubMed] [Google Scholar]
- MURRAY R. G., WOODS P. A. STUDIES ON THE FATE OF LYMPHOCYTES. 3. THE MIGRATION AND METAMORPHOSIS OF IN SITU LABELED THYMIC LYMPHOCYTES. Anat Rec. 1964 Oct;150:113–128. doi: 10.1002/ar.1091500203. [DOI] [PubMed] [Google Scholar]
- Matsuyama M., Wiadrowski M. N., Metcalf D. Autoradiographic analysis of lymphopoiesis and lymphocyte migration in mice bearing multiple thymus grafts. J Exp Med. 1966 Mar 1;123(3):559–576. doi: 10.1084/jem.123.3.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NOSSAL G. J. STUDIES ON THE RATE OF SEEDING OF LYMPHOCYTES FROM THE INTACT GUINEA PIG THYMUS. Ann N Y Acad Sci. 1964 Nov 30;120:171–181. doi: 10.1111/j.1749-6632.1964.tb34715.x. [DOI] [PubMed] [Google Scholar]
- PEPPER F. J. Transplantation of thymic tissue in inbred strains of mice. J Endocrinol. 1961 Jul;22:349–359. doi: 10.1677/joe.0.0220349. [DOI] [PubMed] [Google Scholar]
- Parrott D. V., De Sousa M. A., East J. Thymus-dependent areas in the lymphoid organs of neonatally thymectomized mice. J Exp Med. 1966 Jan 1;123(1):191–204. doi: 10.1084/jem.123.1.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROBINSON S. H., BRECHER G. DELAYED INCORPORATION OF TRITIATED THYMIDINE INTO DNA. Science. 1963 Oct 18;142(3590):392–393. doi: 10.1126/science.142.3590.392. [DOI] [PubMed] [Google Scholar]
- TAYLOR R. B. IMMUNOLOGICAL COMPETENCE OF THYMUS CELLS AFTER TRANSFER TO THYMECTOMIZED RECIPIENTS. Nature. 1963 Aug 31;199:873–874. doi: 10.1038/199873a0. [DOI] [PubMed] [Google Scholar]
- YUNIS E. J., HILGARD H., SJODIN K., MARTINEZ C., GOOD R. A. IMMUNOLOGICAL RECONSTITUTION OF THYMECTOMIZED MICE BY INJECTIONS OF ISOLATED THYMOCYTES. Nature. 1964 Feb 22;201:784–786. doi: 10.1038/201784a0. [DOI] [PubMed] [Google Scholar]