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. 1967 Aug 1;126(2):385–394. doi: 10.1084/jem.126.2.385

STUDIES ON THE PATHOGENESIS OF FEVER

XV. THE PRODUCTION OF ENDOGENOUS PYROGEN BY PERITONEAL MACROPHAGES

Helmut H Hahn 1, David C Char 1, Wilfred B Postel 1, W Barry Wood Jr 1
PMCID: PMC2138324  PMID: 6028492

Abstract

Macrophages from oil-induced peritoneal exudates in rabbits produce endogenous pyrogen when first activated by incubation in 4 hr exudate fluid and then stimulated by incubation in potassium-free isotonic sodium chloride solution. The failure of earlier investigators to obtain pyrogen from macrophages is explained, and the relevance of macrophage pyrogen to fevers of agranulocytosis and other diseases, in which mononuclear rather than granulocytic exudates predominate, is discussed.

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Selected References

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  1. ATKINS E., HEIJN C., Jr STUDIES ON TUBERCULIN FEVER. 3. MECHANISMS INVOLVED IN THE RELEASE OF ENDOGENOUS PYROGEN IN VITRO. J Exp Med. 1965 Aug 1;122:207–235. doi: 10.1084/jem.122.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. ATKINS E., WOOD W. B., Jr Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine. J Exp Med. 1955 Nov 1;102(5):499–516. doi: 10.1084/jem.102.5.499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Allen I. V. A study of the liberation of pyrogen by hypersensitive cells on incubation in vitro with specific antigen. J Pathol Bacteriol. 1965 Jul;90(1):115–122. doi: 10.1002/path.1700900112. [DOI] [PubMed] [Google Scholar]
  4. Atkins E., Bodel P., Francis L. Release of an endogenous pyrogen in vitro from rabbit mononuclear cells. J Exp Med. 1967 Aug 1;126(2):357–384. doi: 10.1084/jem.126.2.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BENNETT I. L., Jr, BEESON P. B. Studies on the pathogenesis of fever. I. The effect of injection of extracts and suspensions of uninfected rabbit tissues upon the body temperature of normal rabbits. J Exp Med. 1953 Nov;98(5):477–492. doi: 10.1084/jem.98.5.477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BENNETT I. L., Jr, BEESON P. B. Studies on the pathogenesis of fever. II. Characterization of fever-producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates. J Exp Med. 1953 Nov;98(5):493–508. doi: 10.1084/jem.98.5.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. BENNETT I. L., Jr Studies on the pathogenesis of fever. III. Failure to demonstrate fever-producing substances in the tissues of leukopenic rabbits. Bull Johns Hopkins Hosp. 1956 Jan;98(1):1–6. [PubMed] [Google Scholar]
  8. BERLIN R. D., WOOD W. B., Jr Molecular mechanisms involved in the release of pyrogen from polymorphonuclear leucocytes. Trans Assoc Am Physicians. 1962;75:190–197. [PubMed] [Google Scholar]
  9. BERLIN R. D., WOOD W. B., Jr STUDIES ON THE PATHOGENESIS OF FEVER. 13. THE EFFECT OF PHAGOCYTOSIS ON THE RELEASE OF ENDOGENOUS PYROGEN BY POLYMORPHONUCLEAR LEUKOCYTES. J Exp Med. 1964 May 1;119:715–726. doi: 10.1084/jem.119.5.715. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. BORNSTEIN D. L., BREDENBERG C., WOOD W. B., Jr Studies on the pathogenesis of fever. XI. Quantitative features of the febrile response to leucocytic pyrogen. J Exp Med. 1963 Mar 1;117:349–364. doi: 10.1084/jem.117.3.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Bodel P., Atkins E. Human leukocyte pyrogen producing fever in rabbits. Proc Soc Exp Biol Med. 1966 Mar;121(3):943–946. doi: 10.3181/00379727-121-30931. [DOI] [PubMed] [Google Scholar]
  12. Bodel P., Atkins E. Release of endogenous pyrogen by human monocytes. N Engl J Med. 1967 May 4;276(18):1002–1008. doi: 10.1056/NEJM196705042761803. [DOI] [PubMed] [Google Scholar]
  13. COLLINS R. D., WOOD W. B., Jr Studies on the pathogenesis of fever. VI. The interaction of leucocytes and endotoxin in vitro. J Exp Med. 1959 Dec 1;110:1005–1016. doi: 10.1084/jem.110.6.1005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Carrel A., Ebeling A. H. THE FUNDAMENTAL PROPERTIES OF THE FIBROBLAST AND THE MACROPHAGE : II. THE MACROPHAGE. J Exp Med. 1926 Aug 31;44(3):285–305. doi: 10.1084/jem.44.3.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. FARR R. S., CLARK S. L., Jr, PROFFITT J. E., CAMPBELL D. H. Some humoral aspects of the development of tolerance to bacterial pyrogens in rabbits. Am J Physiol. 1954 May;177(2):269–278. doi: 10.1152/ajplegacy.1954.177.2.269. [DOI] [PubMed] [Google Scholar]
  16. KAISER H. K., WOOD W. B., Jr Studies on the pathogensis of fever. IX. The production of endogenous pyrogen by polymorphonuclear leucocytes. J Exp Med. 1962 Jan 1;115:27–36. doi: 10.1084/jem.115.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. KING M. K., WOOD W. B., Jr Studies on the pathogenesis of fever. III. The leucocytic origin of endogenous pyrogen in acute inflammatory exudates. J Exp Med. 1958 Feb 1;107(2):279–289. doi: 10.1084/jem.107.2.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. KING M. K., WOOD W. B., Jr Studies on the pathogenesis of fever. IV. The site of action of leucocytic and circulating endogenous pyrogen. J Exp Med. 1958 Feb 1;107(2):291–303. doi: 10.1084/jem.107.2.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. LANDY M., SHEAR M. J. Similarity of host responses elicited by polysaccharides of animal and plant origin and by bacterial endotoxins. J Exp Med. 1957 Jul 1;106(1):77–97. doi: 10.1084/jem.106.1.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. MERLER E., PERRAULT A., TRAPANI R. J., LANDY M., SHEAR M. J. Absence of endotoxic activity in materials derived without bacterial contamination from mammalian tissue. Proc Soc Exp Biol Med. 1960 Dec;105:443–445. doi: 10.3181/00379727-105-26134. [DOI] [PubMed] [Google Scholar]
  21. Rafter G. W., Cheuk S. F., Krause D. W., Wood W. B., Jr Studies on the pathogenesis of fever. XIV. Further observations on the chemistry of leukocytic pyrogen. J Exp Med. 1966 Mar 1;123(3):433–444. doi: 10.1084/jem.123.3.433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. SNELL E. S., ATKINS E. THE PRESENCE OF ENDOGENOUS PYROGEN IN NORMAL RABBIT TISSUES. J Exp Med. 1965 Jun 1;121:1019–1038. doi: 10.1084/jem.121.6.1019. [DOI] [PMC free article] [PubMed] [Google Scholar]

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