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. 1967 Mar 31;125(4):647–656. doi: 10.1084/jem.125.4.647

IN VITRO TRANSFORMATION BY THE ADENOVIRUS-SV40 HYBRID VIRUSES

III. MORPHOLOGY OF TUMORS INDUCED WITH TRANSFORMED CELLS

H J Igel 1, P H Black 1
PMCID: PMC2138363  PMID: 4289742

Abstract

Tumors induced with hamster kidney cells transformed by the adeno 2-, adeno 3-, adeno 7-, and adeno 12-SV40 hybrid viruses, and by adenovirus type 12, were examined histologically. The tumors induced with adeno 2-, adeno 3-, and adeno 7-SV40-transformed cells were similar to tumors induced with SV40-transformed hamster kidney cells but contained cells intermediate in morphology between SV40 and adenovirus tumor cells and occasionally contained nests of adenovirus-like cells. Cells transformed by the adeno 12-SV40 hybrid and by adenovirus type 12 gave rise to morphologically similar tumors. The results suggest that both viral genomes are operative in hybrid-transformed cells but that one genome is apparently responsible for the predominant morphology of the tumor. Evidence that the morphology of a single transformed target cell is determined by the transforming genome was discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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