Abstract
Inoculation of human serums or plasmas obtained during the early acute phase of viral hepatitis induced chemical and morphological hepatic disease in marmosets in two out of five experimental series. The disease was transmissible in series from marmoset to marmoset with an apparent increased virulence of the causative agent in later marmoset passages. The chemical evidence for the disease was elevation of the activity of SGOT and SICD and of serum bilirubin. In serial liver biopsy specimens interpreted under code, a hepatitis, exhibiting some of the characteristics of human viral hepatitis, was readily distinguishable from nonspecific changes. The morphological changes preceded the biochemical alterations and persisted after them. The data reported in these studies indicate that marmosets may be susceptible to human hepatitis. If these observations are confirmed, these animals may provide good experimental models for this disease. Final proof that the hepatitis observed in marmosets is caused by agents of human viral hepatitis is still lacking.
Full Text
The Full Text of this article is available as a PDF (2.0 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BEARCROFT W. G. HISTOLOGICAL STUDIES ON THE LIVERS OF WEST AFRICAN PRIMATES INOCULATED WITH INFECTIOUS HEPATITIS. J Pathol Bacteriol. 1964 Oct;88:511–519. doi: 10.1002/path.1700880214. [DOI] [PubMed] [Google Scholar]
- CAPPS R. B., BENNETT A. M., STOKES J., Jr Endemic infectious hepatitis in an infants' orphanage. I. Epidemiologic studies in student nurses. AMA Arch Intern Med. 1952 Jan;89(1):6–23. doi: 10.1001/archinte.1952.00240010016002. [DOI] [PubMed] [Google Scholar]
- DEINHARDT F., COURTOIS G., DHERTE P., OSTERRIETH P., NINANE G., HENLE G., HENLE W. Studies of liver function tests in chimpanzees after inoculation with human infectious hapatitis virus. Am J Hyg. 1962 May;75:311–321. doi: 10.1093/oxfordjournals.aje.a120252. [DOI] [PubMed] [Google Scholar]
- HENLE G., DEINHARDT F., BERGS V. V., HENLE W. Studies on persistent infections of tissue cultures. I. General aspects of the system. J Exp Med. 1958 Oct 1;108(4):537–560. doi: 10.1084/jem.108.4.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HILLIS W. D. An outbreak of infectious hepatitis among chimpanzee handlers at a United States Air Force Base. Am J Hyg. 1961 May;73:316–328. doi: 10.1093/oxfordjournals.aje.a120191. [DOI] [PubMed] [Google Scholar]
- HOLMES A. W., CALDWELL R. G., DEDMON R. E., DEINHARDT F. ISOLATION AND CHARACTERIZATION OF A NEW HERPES VIRUS. J Immunol. 1964 Apr;92:602–610. [PubMed] [Google Scholar]
- KARMEN A., WROBLEWSKI F., LADUE J. S. Transaminase activity in human blood. J Clin Invest. 1955 Jan;34(1):126–131. doi: 10.1172/JCI103055. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MENGHINI G. One-second needle biopsy of the liver. Gastroenterology. 1958 Aug;35(2):190–199. [PubMed] [Google Scholar]
- PEEBLES T. C., MCCARTHY K., ENDERS J. F., HOLLOWAY A. Behavior of monkeys after inoculation of virus derived from patients with measles and propagated in tissue culture together with observations on spontaneous infections of these animals by an agent exhibiting similar antigenic properties. J Immunol. 1957 Jan;78(1):63–74. [PubMed] [Google Scholar]
- RIGHTSEL W. A., KELTSCH R. A., TAYLOR A. R., BOGGS J. D., McLEAN I. W., Jr, CAPPS R. B., WEISS C. F. Status report on tissue-culture cultivated hepatitis virus. I. Virology laboratory studies. II. Clinical trials. JAMA. 1961 Sep 9;177:671–682. doi: 10.1001/jama.1961.03040360007002. [DOI] [PubMed] [Google Scholar]
- SMETANA H. F. The histologic diagnosis of viral hepatitis by needle biopsy. Gastroenterology. 1954 Apr;26(4):612-25, discussion, 640-4. [PubMed] [Google Scholar]
- WOLFSON S. K., Jr, WILLIAMS-ASHMAN H. G. Isocitric and 6-phosphogluconic dehydrogenases in human blood serum. Proc Soc Exp Biol Med. 1957 Oct;96(1):231–234. doi: 10.3181/00379727-96-23439. [DOI] [PubMed] [Google Scholar]