Abstract
The 24 hr volume flow, cell concentration, and total cell output of thoracic duct fluid from mice with pertussis-induced hyperlymphocytosis were markedly reduced when compared with values obtained in normal animals. An increase in the number of circulating lymphocytes occurred in several of the pertussis-treated mice despite the presence of an indwelling thoracic duct cannula. The drainage from such animals also showed a reduced cell concentration and total cell output. It is suggested that lymphocyte recirculation may be minimal in pertussis-induced lymphocytosis, and the evidence obtained also suggests that lymphocytes may enter the blood stream by direct routes during the course of the reaction.
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Selected References
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- BOAK J. L., WOODRUFF M. F. A MODIFIED TECHNIQUE FOR COLLECTING MOUSE THORACIC DUCT LYMPH. Nature. 1965 Jan 23;205:396–397. doi: 10.1038/205396a0. [DOI] [PubMed] [Google Scholar]
- GESNER B. M., GOWANS J. L. The output of lymphocytes from the thoracic duct of unanaesthetized mice. Br J Exp Pathol. 1962 Aug;43:424–430. [PMC free article] [PubMed] [Google Scholar]
- GOWANS J. L. The effect of the continuous re-infusion of lymph and lymphocytes on the output of lymphocytes from the thoracic duct of unanaesthetized rats. Br J Exp Pathol. 1957 Feb;38(1):67–78. [PMC free article] [PubMed] [Google Scholar]
- GOWANS J. L. The recirculation of lymphocytes from blood to lymph in the rat. J Physiol. 1959 Apr 23;146(1):54–69. doi: 10.1113/jphysiol.1959.sp006177. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morse S. I., Riester S. K. Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. I. Radioautographic analysis of the circulating cells in mice undergoing pertussis-induced hyperleukocytosis. J Exp Med. 1967 Mar 1;125(3):401–408. doi: 10.1084/jem.125.3.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHOOLEY J. Lymphocyte output and lymph flow of thoracic and right lymphatic ducts of anesthetized rats. Proc Soc Exp Biol Med. 1958 Nov;99(2):511–513. doi: 10.3181/00379727-99-24401. [DOI] [PubMed] [Google Scholar]
- SMITH C., HENON B. K. Histological and histochemical study of high endothelium of post-capillary veins of the lymph node. Anat Rec. 1959 Nov;135:207–213. doi: 10.1002/ar.1091350306. [DOI] [PubMed] [Google Scholar]
- VENABLE J. H., COGGESHALL R. A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY. J Cell Biol. 1965 May;25:407–408. doi: 10.1083/jcb.25.2.407. [DOI] [PMC free article] [PubMed] [Google Scholar]