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. 1967 Sep 1;126(3):523–538. doi: 10.1084/jem.126.3.523

THE RELATIONSHIP OF POLYMORPHONUCLEAR LEUKOCYTES TO INFERTILITY IN UTERI CONTAINING FOREIGN BODIES

Earl L Parr 1, Russell W Schaedler 1, James G Hirsch 1
PMCID: PMC2138382  PMID: 6034752

Abstract

A chronic infiltration of polymorphonuclear leukocytes was invariably found in the infertile regions of uteri containing foreign bodies in conventional rats, germfree rats, mice, and rabbits. Polymorphonuclear leukocytes were never found in the fertile regions of these uteri. A foreign body in the uterus of the rat, and probably also the mouse, was associated with a bacterial infection which spread the inflammatory response throughout the horn containing the foreign body, and in the mouse occasionally into the control horn as well. No bacteria could be cultured from the rabbit uterine horn containing a foreign body. In the germfree rat, both the infiltration of polymorphonuclear leukocytes into the uterus and fertility were significantly different from that observed in the conventional rat. Whereas in the conventional rat the inflammation and infertility extended along the entire length of the uterine horn containing a small foreign body, in the germfree rat the inflammation and infertility were closely correlated to the position of the foreign body. As judged by measurements of lysozyme in the uterine lumens of rats and rabbits, polymorphonuclear leukocytes released their contents into solution in the uterine lumen. It is concluded that some substance derived from polymorphonuclear leukocytes may exert toxic effects on fertilized ova or on spermatozoa and thus be responsible for the infertility of uteri containing foreign bodies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buckle A. E., Barnett H. R. Uterine histo-pathology in patients fitted with plastic intrauterine contraceptive devices. J Obstet Gynaecol Br Commonw. 1966 Dec;73(6):993–999. doi: 10.1111/j.1471-0528.1966.tb06128.x. [DOI] [PubMed] [Google Scholar]
  2. CHAUDHURY R. R., TARAK T. K. EFFECT OF INTRAUTERINE SILK THREAD SUTURE ON FERTILITY OF FEMALE RATS. Br Med J. 1965 Jan 2;1(5426):31–32. doi: 10.1136/bmj.1.5426.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DOYLE L. L., MARGOLIS A. J. INTRAUTERINE FOREIGN BODY. I. EFFECT ON REPRODUCTIVE PROCESSES IN THE RAT. Fertil Steril. 1964 Nov-Dec;15:597–606. doi: 10.1016/s0015-0282(16)35404-8. [DOI] [PubMed] [Google Scholar]
  4. Doyle L. L., Margolis A. J. Intrauterine Foreign Body: Effect on Pregnancy in the Rat. Science. 1963 Mar 1;139(3557):833–834. doi: 10.1126/science.139.3557.833. [DOI] [PubMed] [Google Scholar]
  5. GREENWALD G. S. INTERRUPTION OF PREGNANCY IN THE RAT BY A UTERINE SUTURE. J Reprod Fertil. 1965 Feb;9:9–17. doi: 10.1530/jrf.0.0090009. [DOI] [PubMed] [Google Scholar]
  6. Ginther O. J., Pope A. L., Casida L. E. Local effect of an intrauterine plastic coil on the corpus luteum of the ewe. J Anim Sci. 1966 May;25(2):472–475. doi: 10.2527/jas1966.252472x. [DOI] [PubMed] [Google Scholar]
  7. Ginther O. J., Woody C. O., Janakiraman K., Casida L. E. Effect of an intra-uterine plastic coil on the oestrous cycle of the heifer. J Reprod Fertil. 1966 Aug;12(1):193–198. doi: 10.1530/jrf.0.0120193. [DOI] [PubMed] [Google Scholar]
  8. Hall H. H., Sedlis A., Chabon I., Stone M. L. Effect of intrauterine stainless steel ring on endometrial structure and function. Am J Obstet Gynecol. 1965 Dec 1;93(7):1031–1041. doi: 10.1016/0002-9378(65)90168-7. [DOI] [PubMed] [Google Scholar]
  9. Hall H. H. The band, a new intrauterine contraceptive device. Am J Obstet Gynecol. 1966 Jul 15;95(6):879–880. doi: 10.1016/0002-9378(66)90096-2. [DOI] [PubMed] [Google Scholar]
  10. Hawk H. W. Inhibition of ovum fertilization in the ewe by intra-uterine plastic spirals. J Reprod Fertil. 1965 Oct;10(2):267–269. doi: 10.1530/jrf.0.0100267. [DOI] [PubMed] [Google Scholar]
  11. Morese K. N., Peterson W. F., Allen S. T. Endometrial effects of an intrauterine contraceptive device. Obstet Gynecol. 1966 Sep;28(3):323–328. [PubMed] [Google Scholar]
  12. Morgenstern L. L., Orgebin-Crist M. C., Clewe T. H., Bonney W. A., Noyes R. W. Observations on spermatozoa in the human uterus and oviducts in the chronic presence of intrauterine devices. Am J Obstet Gynecol. 1966 Sep 1;96(1):114–118. doi: 10.1016/s0002-9378(16)34649-x. [DOI] [PubMed] [Google Scholar]
  13. Rozin S., Sacks M. I., Shenker J. G. Endometrial histology and clinical symptoms following prolonged retention of uterine contraceptive devices. Am J Obstet Gynecol. 1967 Jan 15;97(2):197–202. doi: 10.1016/0002-9378(67)90540-6. [DOI] [PubMed] [Google Scholar]
  14. Tietze C. Contraception with intrauterine devices. 1959-1966. Am J Obstet Gynecol. 1966 Dec 1;96(7):1043–1054. doi: 10.1016/0002-9378(66)90455-8. [DOI] [PubMed] [Google Scholar]
  15. Willson J. R., Ledger W. J., Andros G. J. The effect of an intrauterine contraceptive device on the histologic pattern of the endometrium. Am J Obstet Gynecol. 1965 Nov 15;93(6):802–811. doi: 10.1016/0002-9378(65)90081-5. [DOI] [PubMed] [Google Scholar]

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