Abstract
Experiments utilizing chromosome marker and histological techniques in combination with parabiosis and transplanatation procedures have demonstrated an inflow of blood-home stem cells into the chick embryo thymic rudiment. There is close similarity between the histological picture in the chick and in the mouse thymic rudiment, and it is proposed that a similar developmental process takes place in both. It may be concluded that the epithelial component of the thymic rudiment, rather than producing lymphoid cells itself, furnishes an inductive environment for the proliferation and differentiation of stem cells derived extrinsically.
Full Text
The Full Text of this article is available as a PDF (1.1 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ACKERMAN G. A., KNOUFF R. A. LYMPHOCYTE FORMATION IN THE THYMUS OF THE EMBRYONIC CHICK. Anat Rec. 1964 Jun;149:191–215. doi: 10.1002/ar.1091490204. [DOI] [PubMed] [Google Scholar]
- AUERBACH R. Experimental analysis of the origin of cell types in the development of the mouse thymus. Dev Biol. 1961 Jun;3:336–354. doi: 10.1016/0012-1606(61)90051-3. [DOI] [PubMed] [Google Scholar]
- AUERBACH R. Morphogenetic interactions in the development of the mouse thymus gland. Dev Biol. 1960 Jun;2:271–284. doi: 10.1016/0012-1606(60)90009-9. [DOI] [PubMed] [Google Scholar]
- Gottesman J. M., Jaffe H. L. STUDIES ON THE HISTOGENESIS OF AUTOPLASTIC THYMUS TRANSPLANTATIONS. J Exp Med. 1926 Feb 28;43(3):403–414. doi: 10.1084/jem.43.3.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARRIS J. E., FORD C. E. CELLULAR TRAFFIC OF THE THYMUS: EXPERIMENTS WITH CHROMOSOME MARKERS. EVIDENCE THAT THE THYMUS PLAYS AN INSTRUCTIONAL PART. Nature. 1964 Feb 29;201:884–885. doi: 10.1038/201884a0. [DOI] [PubMed] [Google Scholar]
- Hancox N. M. The survival of transplanted embryo bone grafted to chorioallantoic membrane, and subsequent osteogenesis. J Physiol. 1947 Jul 31;106(3):279–285. doi: 10.1113/jphysiol.1947.sp004211. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moore M. A., Owen J. J. Chromosome marker studies on the development of the haemopoietic system in the chick embryo. Nature. 1965 Dec 4;208(5014):956–passim. doi: 10.1038/208956a0. [DOI] [PubMed] [Google Scholar]
- Moscona A. THE DEVELOPMENT IN VITRO OF CHIMERIC AGGREGATES OF DISSOCIATED EMBRYONIC CHICK AND MOUSE CELLS. Proc Natl Acad Sci U S A. 1957 Jan 15;43(1):184–194. doi: 10.1073/pnas.43.1.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Owen J. J. Karyotype studies on Gallus domesticus. Chromosoma. 1965 May 26;16(5):601–608. doi: 10.1007/BF00326975. [DOI] [PubMed] [Google Scholar]
- Pierce G. B. The development of basement membranes of the mouse embryo. Dev Biol. 1966 Apr;13(2):231–249. doi: 10.1016/0012-1606(66)90066-2. [DOI] [PubMed] [Google Scholar]
- Rosen F. S., Janeway C. A. The gamma globulins. 3. The antibody deficiency syndromes. N Engl J Med. 1966 Oct 6;275(14):769–concl. doi: 10.1056/NEJM196610062751407. [DOI] [PubMed] [Google Scholar]
- SMITH C. STUDIES ON THE THYMUS OF THE MAMMAL. XIV. HISTOLOGY AND HISTOCHEMISTRY OF EMBRYONIC AND EARLY POSTNATAL THYMUSES OF C57BL-6 AND AKR STRAIN MICE. Am J Anat. 1965 May;116:611–629. doi: 10.1002/aja.1001160307. [DOI] [PubMed] [Google Scholar]
- VENZKE W. G. Morphogenesis of the thymus of chicken embryos. Am J Vet Res. 1952 Jul;13(48):395–404. [PubMed] [Google Scholar]
- WEAKLEY B. S., PATT D. I., SHEPRO D. ULTRASTRUCTURE OF THE FETAL THYMUS IN THE GOLDEN HAMSTER. J Morphol. 1964 Nov;115:319–354. doi: 10.1002/jmor.1051150303. [DOI] [PubMed] [Google Scholar]