Abstract
The hypothesis that treatment with antilymphocytic serum (ALS) can provoke latent virus infections has been investigated. In adult mice infections with sublethal doses of LCM virus usually result in the development of immunity to the virus and at the same time to a prolonged latent infection. In the experiments described an intensive treatment with large doses of ALS was given to mice which had recovered from LCM virus infection. At the beginning of the treatment the mice had high titers of complement-fixing antibodies in their blood and no detectable virus. The data presented show that in spite of the immunity the ALS treatment provoked the occult virus and led to the development of viremia in all the treated mice. In some, very high virus titers were demonstrable. When the ALS treatment was discontinued the viremia disappeard again. In most of the mice the ALS did not suppress the complement-fixing antibody titers and in some there was even a considerable increase in titer. In such cases the increases in virus titers and in antibody titers were closely related to one another. These results demonstrate once again that the complement-fixing antibodies to the LCM virus in mice probably do not influence the virus.
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Selected References
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- Calne R. Y., Davis D. R., Medawar P., Wheeler J. R. Effect of donor antigen on dogs with renal homotransplants. Transplantation. 1966 Nov;4(6):742–746. doi: 10.1097/00007890-196611000-00009. [DOI] [PubMed] [Google Scholar]
- Gray J. G., Monaco A. P., Wood M. L., Russell P. S. Studies on heterologous anti-lymphocyte serum in mice. I. In vitro and in vivo properties. J Immunol. 1966 Feb;96(2):217–228. [PubMed] [Google Scholar]
- HAAS V. H. Some relationships between lymphocytic choriomeningitis (LCM) virus and mice. J Infect Dis. 1954 Mar-Apr;94(2):187–198. doi: 10.1093/infdis/94.2.187. [DOI] [PubMed] [Google Scholar]
- Klein G. Tumor antigens. Annu Rev Microbiol. 1966;20:223–252. doi: 10.1146/annurev.mi.20.100166.001255. [DOI] [PubMed] [Google Scholar]
- Larsen J. H., Volkert M. Studies on immunological tolerance to LCM virus. 7. Adoptive immunization of virus carrier mice by grafts of normal syngeneic lymphoid cells. Acta Pathol Microbiol Scand. 1967;70(1):95–106. [PubMed] [Google Scholar]
- MOELLER E. CONTACT-INDUCED CYTOTOXICITY BY LYMPHOID CELLS CONTAINING FOREIGN ISOANTIGENS. Science. 1965 Feb 19;147(3660):873–879. doi: 10.1126/science.147.3660.873. [DOI] [PubMed] [Google Scholar]
- Monaco A. P., Wood M. L., Gray J. G., Russell P. S. Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response. J Immunol. 1966 Feb;96(2):229–238. [PubMed] [Google Scholar]
- SINKOVICS J. Virus Neutralisation experiments with lymphoid cell- and lymph node-extracts. Acta Microbiol Acad Sci Hung. 1955;2(4):385–400. [PubMed] [Google Scholar]
- Smadel J. E., Wall M. J. A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. INDEPENDENCE OF ANTI-SOLUBLE SUBSTANCE ANTIBODIES AND NEUTRALIZING ANTIBODIES, AND THE ROLE OF SOLUBLE ANTIGEN AND INACTIVE VIRUS IN IMMUNITY TO INFECTION. J Exp Med. 1940 Sep 30;72(4):389–405. doi: 10.1084/jem.72.4.389. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VOLKERT M., LARSEN J. H., PFAU C. STUDIES ON IMMUNOLOGICAL TOLERANCE TO LCM VIRUS. 4. THE QUESTION OF IMMUNITY IN ADOPTIVELY IMMUNIZED VIRUS CARRIERS. Acta Pathol Microbiol Scand. 1964;61:268–282. doi: 10.1111/apm.1964.61.2.268. [DOI] [PubMed] [Google Scholar]
- VOLKERT M., LARSEN J. H. STUDIES ON IMMUNOLOGICAL TOLERANCE TO LCM VIRUS. 5. THE INDUCTION OF TOLERANCE TO THE VIRUS. Acta Pathol Microbiol Scand. 1965;63:161–171. doi: 10.1111/apm.1965.63.2.161. [DOI] [PubMed] [Google Scholar]
- VOLKERT M. STUDIES ON IMMUNOLOGICAL TOLERANCE TO LCM VIRUS. 2. TREATMENT OF VIRUS CARRIER MICE BY ADOPTIVE IMMUNIZATION. Acta Pathol Microbiol Scand. 1963;57:465–487. [PubMed] [Google Scholar]
- VOLKERT M. Studies on immunological tolerance to LCM virus. A preliminary report on adoptive immunization of virus carrier mice. Acta Pathol Microbiol Scand. 1962;56:305–310. [PubMed] [Google Scholar]
- Volkert M., Larsen J. H. Immunological tolerance to viruses. Prog Med Virol. 1965;7:160–207. [PubMed] [Google Scholar]
- WEIGAND H., HOTCHIN J. Studies of lymphocytic choriomeningitis in mice. II. A comparison of the immune status of newborn and adult mice surviving inoculation. J Immunol. 1961 Apr;86:401–406. [PubMed] [Google Scholar]
- WOODRUFF M. F., ANDERSON N. F. THE EFFECT OF LYMPHOCYTE DEPLETION BY THORACIC DUCT FISTULA AND ADMINISTRATION OF ANTILYMPHOCYTIC SERUM ON THE SURVIVAL OF SKIN HOMOGRAFTS IN RATS. Ann N Y Acad Sci. 1964 Nov 30;120:119–128. doi: 10.1111/j.1749-6632.1964.tb34710.x. [DOI] [PubMed] [Google Scholar]