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. 1968 Feb 29;127(3):507–522. doi: 10.1084/jem.127.3.507

PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NZB/W MICE

P H Lambert 1, Frank J Dixon 1
PMCID: PMC2138462  PMID: 4169964

Abstract

The development of glomerulonephritis in NZB/W mice is closely related to the formation of antinuclear, particularly anti-DNA, antibodies. The developing inflammatory glomerular lesions are characterized by the deposition of γG- and β1C-globulins plus DNA and possibly other nuclear antigens, presumably as complexes, in a granular to lumpy pattern along the capillary walls and in the mesangia. Elution studies revealed the γG-globulin in the glomeruli to be largely γG2A-type antibody to soluble nuclear antigens. Enhancement of the antinuclear antibody response by active immunization of young NZB/W mice with DNA-methylated BSA hastens the development and increases the severity of the glomerulonephritis. Similarly, injections of soluble DNA into NZB/W mice with circulating anti-DNA antibodies but with as yet little nephritis causes rapid progression of nephritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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