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. 1968 Mar 31;127(4):717–730. doi: 10.1084/jem.127.4.717

HETEROLOGOUS CARRIERS IN THE ANAMNESTIC ANTIHAPTEN RESPONSE

Marvin B Rittenberg 1, Dan H Campbell 1
PMCID: PMC2138479  PMID: 4171054

Abstract

Anamnestic antihapten responses were obtained to trinitrophenyl (TNP) when rabbits sensitized to trinitrophenyl-hemocyanin (TNP-KLH) were challenged with TNP-heterologous protein conjugates. Hapten-heterologous carrier conjugates elicited antihapten titers similar in magnitude to those elicited by the homologous carrier conjugate. Hapten-heterologous carrier recall of antihapten was successful as early as 37 days and as late as 11 months after sensitization. There was no correlation between anti-TNP-precipitating antibody titer after sensitization and the ability to respond to challenge by hapten-heterologous carrier. The results are discussed in terms of immunogenicity of sensitization, suppressive effects of persisting postsensitization antibody, and submolecular haptenic environment as factors possibly affecting the heterologous recall process.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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