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. 1968 May 1;127(5):915–926. doi: 10.1084/jem.127.5.915

PERSISTENCE OF IMMUNOGENICITY OF ANTIGEN AFTER UPTAKE BY MACROPHAGES

Emil R Unanue 1, Brigitte A Askonas 1
PMCID: PMC2138486  PMID: 5655102

Abstract

Peritoneal macrophages were cultured for several hours after uptake of 131I-hemocyanin. The cells degraded most of the 131I-labeled protein within 2–5 hr. Their ability to prime lymphocytes of syngeneic mice for a secondary immune challenge remained unchanged for long periods of time despite the loss of more than 90% of the original content of antigen. The persistence of immunogenicity was associated with a small percentage of antigen retained by the cell in a form which was protected from rapid breakdown and elimination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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