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. 1968 Oct 31;128(5):877–894. doi: 10.1084/jem.128.5.877

THE EFFECT OF ACETYLSALICYLIC ACID ON PLATELET FUNCTION

Geoffrey Evans 1, Marian A Packham 1, Edward E Nishizawa 1, James F Mustard 1, Edmund A Murphy 1
PMCID: PMC2138560  PMID: 4176225

Abstract

Acetylsalicylic acid (ASA, aspirin) and sodium salicylate inhibit platelet aggregation induced by collagen, antigen-antibody complexes, gamma globulin-coated particles or thrombin. These compounds suppress the release of platelet constituents, such as adenosine diphosphate (ADP) and serotonin, induced by such stimuli. Since ASA and sodium salicylate do not inhibit ADP-induced platelet aggregation, it appears that their effect on the action of the other stimuli is due to a decrease in the amount of ADP released. The administration of ASA to rabbits (in doses which inhibited collagen-induced platelet aggregation) impaired hemostasis, prolonged platelet survival, and diminished the amount of deposit formed in an extracorporeal shunt.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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