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. 1968 Nov 30;128(6):1353–1362. doi: 10.1084/jem.128.6.1353

CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES

MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES

Herbert J Shulman 1, Karl Meyer 1
PMCID: PMC2138571  PMID: 5688079

Abstract

Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate. Chicken embryonic cartilage was shown to be composed mainly of chondroitin-4-sulfate, with a small amount of chondroitin-6-sulfate, but essentially no keratan sulfate. These findings were compared to the data of others, and a hypothesis explaining the aging process in cartilage in terms of cellular differentiation was presented.

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Selected References

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