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. 1969 Jan 1;129(1):37–49. doi: 10.1084/jem.129.1.37

RELATION OF RHEUMATIC-LIKE CARDIAC LESIONS OF THE MOUSE TO LOCALIZATION OF GROUP A STREPTOCOCCAL CELL WALLS

S H Ohanian 1, J H Schwab 1, W J Cromartie 1
PMCID: PMC2138592  PMID: 5782771

Abstract

Mice injected intraperitoneally with isolated cell wall fragments of Group A streptococci develop a carditis similar to that previously observed in mice injected with crude extracts of this organism. Neither the soluble cytoplasmic components of Group A streptococcal cells nor the nonfragmented cell walls produced carditis in this experimental model. Fluorescein and 125I-labeled antibodies specific for Group A streptococcal cell wall antigens were used to demonstrate that, for 5 wk after injection, cell wall material is localized around the sites of active lesions in the heart. In addition, the cell wall antigen accumulates in the liver, spleen, mediastinal lymph nodes, and the adjacent loose connective tissue, where it persists for at least 10 wk.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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