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. 1969 Jan 1;129(1):123–139. doi: 10.1084/jem.129.1.123

RELATIVE INABILITY TO INDUCE TOLERANCE IN ADULT NZB AND NZB/NZW F1 MICE

Parker J Staples 1, Norman Talal 1
PMCID: PMC2138594  PMID: 4178111

Abstract

Immunologic tolerance to ultracentrifuged bovine gamma globulin could not be induced in 6-wk old NZB or B/W mice, but developed readily in C3H, NZW, and C57Bl mice. NZB and B/W mice, as well as Balb/c mice, failed to become tolerant to ultracentrifuged human gamma globulin. The NZB and B/W mice also showed higher antibody titers to a standard antigenic challenge. This immunologic hyperreactivity and lack of experimental tolerance may be related to the lack of self-tolerance, autoimmunity, and lymphomas that develop in these mice at a later age.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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