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. 1969 May 1;129(5):897–907. doi: 10.1084/jem.129.5.897

THE X-Y-Z SCHEME OF IMMUNOCYTE MATURATION

VII. CELL DIVISION AND THE ESTABLISHMENT OF SHORT-TERM IGM MEMORY

Patricia Byfield 1, Eli Sercarz 1
PMCID: PMC2138634  PMID: 5305241

Abstract

Short-term IgM memory is established within 1 day after primary injection. This 1 day priming is independent of cell division as it can take place in the pressence of methotrexate or hydroxyurea. The primary response involves a similar 1 day nonproliferative phase. On the contrary, cells responding to a second injection of antigen after short priming intervals begin to proliferate within hours. This implies a qualitative difference between the antigen-sensitive cells in primed and normal animals. After 1 day, further proliferative expansion of memory can occur, which is probably antigen dependent. The response to several dose regimens indicates that repeated antigenic contact is needed to maintain the IgM response.

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Selected References

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