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. 1969 Jun 1;129(6):1367–1384. doi: 10.1084/jem.129.6.1367

HUMAN IMMUNITY TO THE MENINGOCOCCUS

IV. IMMUNOGENICITY OF GROUP A AND GROUP C MENINGOCOCCAL POLYSACCHARIDES IN HUMAN VOLUNTEERS

Emil C Gotschlich 1, Irving Goldschneider 1, Malcolm S Artenstein 1
PMCID: PMC2138657  PMID: 4977283

Abstract

High molecular weight group A and group C meningococcal polysaccharides had no significant toxicity for mice or guinea pigs. Furthermore, these polysaccharide preparations contained negligible amounts of biologically active endotoxin. The high molecular weight group A and group C meningococcal polysaccharides were excellent immunogens in six human volunteers. Antibodies belonging to the immunoglobulin classes IgG, IgM, and IgA were produced. These antibodies were highly meningococcocidal in the presence of complement.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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