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. 1969 Jul 1;130(1):165–184. doi: 10.1084/jem.130.1.165

CELLS INVOLVED IN THE IMMUNE RESPONSE

XI. IDENTIFICATION OF THE ANTIGEN-REACTIVE CELL AS THE TOLERANT CELL IN THE IMMUNOLOGICALLY TOLERANT RABBIT

Nabih I Abdou 1, Maxwell Richter 1
PMCID: PMC2138669  PMID: 4183777

Abstract

Rabbits were made immunologically tolerant to either human serum albumin or bovine gamma globulin by the neonatal administration of antigen. At 10 wk of age, they were challenged with the tolerogenic antigen and found to be non-responsive. However, these tolerant rabbits could respond with humoral antibody formation directed toward the tolerogenic antigen if they were treated with normal, allogeneic bone marrow or bone marrow obtained from a rabbit made tolerant toward a different antigen. They were incapable of responding if they were given bone marrow obtained from a rabbit previously made tolerant to the tolerogenic antigen. Irradiated rabbits were unable to respond if treated with tolerant bone marrow, but could respond well if given normal bone marrow. Since it has previously been demonstrated that the antibody-forming cell, in an irradiated recipient of allogeneic bone marrow, is of recipient and not donor origin, the data presented strongly indicate that the unresponsive cell in the immunologically tolerant rabbit is the antigen-reactive cell.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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