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. 1969 Nov 30;130(6):1411–1425. doi: 10.1084/jem.130.6.1411

IMMUNOLOGICAL EFFECTS OF THERMAL INJURY

I. INHIBITION OF SPERMATOGENESIS IN GUINEA PIGS

Felix T Rapaport 1, Angus Sampath 1, Kyiochi Kano 1, Robert T McCluskey 1, Felix Milgrom 1
PMCID: PMC2138690  PMID: 4982027

Abstract

Unilateral thermal injury to guinea pig testes has elicited the formation of organ- and species-specific antibodies against a testicular antigen. The antibodies were of an IgG1 nature, and reacted with autologous as well as homologous testicular extracts. A significant number of burned animals showed pathological changes in the contralateral testis, which were similar to those observed after the induction of experimental allergic orchitis by active immunization with testicular tissue. These results indicate that thermal injury may be associated with autoimmunization of the host by the injured organ.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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