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. 1969 Oct 1;130(4):867–876. doi: 10.1084/jem.130.4.867

CELLS INVOLVED IN THE IMMUNE RESPONSE

VIII. THE RELATIONSHIP BETWEEN THE LOSS AND REAPPEARANCE OF ANTIGEN-REACTIVE CELLS AND IMMUNE RESPONSIVENESS AFTER IRRADIATION OF NORMAL ADULT RABBITS

Nabih I Abdou 1, Bram Rose 1, Maxwell Richter 1
PMCID: PMC2138722  PMID: 5343438

Abstract

By appropriate irradiation and cell transfer experiments, a direct correlation was observed between the presence of viable and immunologically active antigen-reactive cells and the capacity of the rabbits to respond following immunization. Rabbits given 800 R total body irradiation were unable to elicit a humoral immune response nor did they possess significant numbers of antigen-reactive cells. The ability to respond with humoral antibody formation did not reappear until antigen-reactive cells could be detected. These results strongly indicate that the presence of competent antigen-reactive cells are necessary for the successful induction of the humoral immune response in the rabbit.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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