Skip to main content
PMC home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1970 Jan 1;131(1):1–19. doi: 10.1084/jem.131.1.1

PATHOGENESIS OF CHRONIC DISEASE ASSOCIATED WITH PERSISTENT LYMPHOCYTIC CHORIOMENINGITIS VIRAL INFECTION

II. RELATIONSHIP OF THE ANTI-LYMPHOCYTIC CHORIOMENINGITIS IMMUNE RESPONSE TO TISSUE INJURY IN CHRONIC LYMPHOCYTIC CHORIOMENINGITIS DISEASE

Michael B A Oldstone 1, Frank J Dixon 1
PMCID: PMC2138769  PMID: 5460613

Abstract

Tissue injury (chronic disease) associated with persistent LCM infection is apparently caused by the host immune response to the virus. Employing parabiosis or cell transfer from hyperimmune donors to isologous virus carriers, the tissue injury of chronic disease could be initiated and/or intensified. Furthermore, the transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells. The pathogenesis of the nonglomerular tissue injury of chronic LCM disease is apparently at least in part related to the interaction of circulating anti-LCM antibody with viral antigen at the tissue site. Trapping of circulating virus-antibody complexes in the glomerular filter is apparently the major cause of the glomerulonephritis.

Full Text

The Full Text of this article is available as a PDF (1.4 MB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker F. D., Hotchin J. Slow virus kidney disease of mice. Science. 1967 Oct 27;158(3800):502–504. doi: 10.1126/science.158.3800.502. [DOI] [PubMed] [Google Scholar]
  2. GELL P. G., HINDE I. T. Observations on the histology of the Arthus reaction and its relation to other known types of skin hypersensitivity. Int Arch Allergy Appl Immunol. 1954;5(1):23–46. doi: 10.1159/000228084. [DOI] [PubMed] [Google Scholar]
  3. HAAS V. H., STEWART S. E. Sparing effect of A-methopterin and guanazolo in mice infected with virus of lymphocytic choriomeningitis. Virology. 1956 Aug;2(4):511–516. doi: 10.1016/0042-6822(56)90007-1. [DOI] [PubMed] [Google Scholar]
  4. HOTCHIN J. E., CINITS M. Lymphocytic choriomeningitis infection of mice as a model for the study of latent virus infection. Can J Microbiol. 1958 Apr;4(2):149–163. doi: 10.1139/m58-016. [DOI] [PubMed] [Google Scholar]
  5. HOTCHIN J. The biology of lymphocytic choriomeningitis infection: virus-induced immune disease. Cold Spring Harb Symp Quant Biol. 1962;27:479–499. doi: 10.1101/sqb.1962.027.001.046. [DOI] [PubMed] [Google Scholar]
  6. HOTCHIN J., WEIGAND H. The effects of pretreatment with x-rays on the pathogenesis of lymphocytic choriomeningitis in mice. I. Host survival, virus multiplication and leukocytosis. J Immunol. 1961 Dec;87:675–681. [PubMed] [Google Scholar]
  7. Hirsch M. S., Murphy F. A., Russe H. P., Hicklin M. D. Effects of anti-thymocyte serum on lymphocytic choriomeningitis (LCM) virus infection in mice. Proc Soc Exp Biol Med. 1967 Jul;125(3):980–983. doi: 10.3181/00379727-125-32254. [DOI] [PubMed] [Google Scholar]
  8. LI C. P., HABEL K. Adaptation of Leon strain of poliomyelitis to mice. Proc Soc Exp Biol Med. 1951 Oct;78(1):233–238. doi: 10.3181/00379727-78-19032. [DOI] [PubMed] [Google Scholar]
  9. NOTKINS A. L. LACTIC DEHYDROGENASE VIRUS. Bacteriol Rev. 1965 Jun;29:143–160. doi: 10.1128/br.29.2.143-160.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Oldstone M. B., Dixon F. J. Direct immunofluorescent tissue culture assay for lymphocytic choriomeningitis virus. J Immunol. 1968 May;100(5):1135–1138. [PubMed] [Google Scholar]
  11. Oldstone M. B., Dixon F. J. Immunohistochemical study of allergic encephalomyelitis. Am J Pathol. 1968 Feb;52(2):251–263. [PMC free article] [PubMed] [Google Scholar]
  12. Oldstone M. B., Dixon F. J. Lymphocytic choriomeningitis: production of antibody by "tolerant" infected mice. Science. 1967 Dec 1;158(3805):1193–1195. doi: 10.1126/science.158.3805.1193. [DOI] [PubMed] [Google Scholar]
  13. Oldstone M. B., Dixon F. J. Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice. J Exp Med. 1969 Mar 1;129(3):483–505. doi: 10.1084/jem.129.3.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Oldstone M. B., Dixon F. J. Susceptibility of different mouse strains to lymphocytic choriomeningitis virus. J Immunol. 1968 Feb;100(2):355–357. [PubMed] [Google Scholar]
  15. Pedersen I. R., Volkert M. Multiplication of lymphocytic choriomeningitis virus in suspension cultures of Earle's strain L cells. Acta Pathol Microbiol Scand. 1966;67(4):523–536. doi: 10.1111/apm.1966.67.4.523. [DOI] [PubMed] [Google Scholar]
  16. Porter D. D., Larsen A. E., Porter H. G. The pathogenesis of Aleutian disease of mink. I. In vivo viral replication and the host antibody response to viral antigen. J Exp Med. 1969 Sep 1;130(3):575–593. doi: 10.1084/jem.130.3.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. ROBERTS J. C., Jr, DIXON F. J. The transfer of lymph node cells in the study of the immune response to foreign proteins. J Exp Med. 1955 Oct 1;102(4):379–392. doi: 10.1084/jem.102.4.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. ROWE W. P. Protective effect of pre-irradiation on lymphocytic choriomeningitis infection in mice. Proc Soc Exp Biol Med. 1956 May;92(1):194–198. doi: 10.3181/00379727-92-22425. [DOI] [PubMed] [Google Scholar]
  19. Traub E. EPIDEMIOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS IN A MOUSE STOCK OBSERVED FOR FOUR YEARS. J Exp Med. 1939 May 31;69(6):801–817. doi: 10.1084/jem.69.6.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Traub E. PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY. J Exp Med. 1936 May 31;63(6):847–861. doi: 10.1084/jem.63.6.847. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Traub E. THE EPIDEMIOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS IN WHITE MICE. J Exp Med. 1936 Jul 31;64(2):183–200. doi: 10.1084/jem.64.2.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. UNANUE E., DIXON F. J. EXPERIMENTAL GLOMERULONEPHRITIS. IV. PARTICIPATION OF COMPLEMENT IN NEPHROTOXIC NEPHRITIS. J Exp Med. 1964 Jan 1;119:965–982. doi: 10.1084/jem.119.6.965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. VOLKERT M., LARSEN J. H. STUDIES ON IMMUNOLOGICAL TOLERANCE TO LCM VIRUS. 3. DURATION AND MAXIMAL EFFECT OF ADOPTIVE IMMUNIZATION OF VIRUS CARRIERS. Acta Pathol Microbiol Scand. 1964;60:577–587. doi: 10.1111/apm.1964.60.4.577. [DOI] [PubMed] [Google Scholar]
  24. VOLKERT M., LARSEN J. H. STUDIES ON IMMUNOLOGICAL TOLERANCE TO LCM VIRUS. 6. IMMUNITY CONFERRED ON TOLERANT MICE BY IMMUNE SERUM AND BY GRAFTS OF HOMOLOGOUS LYMPHOID CELLS. Acta Pathol Microbiol Scand. 1965;63:172–180. doi: 10.1111/apm.1965.63.2.172. [DOI] [PubMed] [Google Scholar]
  25. VOLKERT M. STUDIES ON IMMUNOLOGICAL TOLERANCE TO LCM VIRUS. 2. TREATMENT OF VIRUS CARRIER MICE BY ADOPTIVE IMMUNIZATION. Acta Pathol Microbiol Scand. 1963;57:465–487. [PubMed] [Google Scholar]
  26. Volkert M., Larsen J. H. Immunological tolerance to viruses. Prog Med Virol. 1965;7:160–207. [PubMed] [Google Scholar]
  27. WAKSMAN B. H., ADAMS R. D. A histologic study of the early lesion in experimental allergic encephalomyelitis in the guinea pig and rabbit. Am J Pathol. 1962 Aug;41:135–162. [PMC free article] [PubMed] [Google Scholar]
  28. WILSNACK R. E., ROWE W. P. IMMUNOFLUORESCENT STUDIES OF THE HISTOPATHOGENESIS OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION. J Exp Med. 1964 Nov 1;120:829–840. doi: 10.1084/jem.120.5.829. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES