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. 1970 Mar 31;131(4):817–831. doi: 10.1084/jem.131.4.817

INTERACTIONS OF THE COMPLEMENT SYSTEM WITH ENDOTOXIC LIPOPOLYSACCHARIDES IN IMMUNOGLOBULIN-DEFICIENT SERA

H Gewurz 1, R J Pickering 1, R Snyderman 1, L M Lichtenstein 1, R A Good 1, S E Mergenhagen 1
PMCID: PMC2138773  PMID: 4193936

Abstract

Bacterial lipopolysaccharides (LPS) derived from a variety of organisms effectively induced C consumption in humans, bovines, and porcines with developmental agammaglobulinemia; birds with experimental agammaglobulinemia; and humans with agammaglobulinemia syndromes. This interaction proceeded even in precolostral piglet sera which contained less than 2.5 x 10–6 mg/ml gamma globulin, and led to generation of neutrophil chemotactic factor and anaphylatoxin in these sera. Hence, the LPS-C interaction can proceed in sera markedly deficient in immunoglobulin. The question of whether immunoglobulins can be bypassed in the LPS-C interaction, or whether they are regularly utilized in a way so efficient that their participation is masked, was considered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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