Abstract
A series of pulse-doses of 7, 8, 12-trimethylbenz(a)anthracene-induced leukemia rapidly and consistently in very high yield in rats of Long-Evans (L-E) strain. The predominant type was a diffuse hepatic leukemia of erythroblastic stem cells. Progressive hypothermia and a decline in pituitary function are newly recognized signs of advanced leukemia in rat.
Full Text
The Full Text of this article is available as a PDF (589.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ford E., Huggins C. SELECTIVE DESTRUCTION IN TESTIS INDUCED BY 7,12-DIMETHYLBENZ [a] ANTHRACENE. J Exp Med. 1963 Jul 1;118(1):27–40. doi: 10.1084/jem.118.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUGGINS C., MORII S. Selective adrenal necrosis and apoplexy induced by 7, 12-dimethylbenz(a)anthracene. J Exp Med. 1961 Nov 1;114:741–760. doi: 10.1084/jem.114.5.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Huggins C. B., Sugiyama T. Induction of leukemia in rat by pulse doses of 7,12-dimethylbenz(a)anthracene. Proc Natl Acad Sci U S A. 1966 Jan;55(1):74–81. doi: 10.1073/pnas.55.1.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Huggins C., Morii S., Pataki J. Selective destruction of adrenal cortex by pulse doses of derivatives of 12-methylbenz(a)anthracene. Proc Natl Acad Sci U S A. 1969 Mar;62(3):704–707. doi: 10.1073/pnas.62.3.704. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schurr P. E. Composition and preparation of experimental intravenous fat emulsions. Cancer Res. 1969 Jan;29(1):258–260. [PubMed] [Google Scholar]
- Uematsu K., Huggins C. Induction of leukemia and ovarian tumors in mice by pulse-doses of polycyclic aromatic hydrocarbons. Mol Pharmacol. 1968 Sep;4(5):427–434. [PubMed] [Google Scholar]