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. 1970 Sep 1;132(3):417–439. doi: 10.1084/jem.132.3.417

CHRONIC ALLOGENEIC DISEASE

II. DEVELOPMENT OF LYMPHOMAS

Martine Y K Armstrong 1, Ernst Gleichmann 1, Helga Gleichmann 1, Lorraine Beldotti 1, Janine Andre-Schwartz 1, Robert S Schwartz 1
PMCID: PMC2138811  PMID: 5523966

Abstract

The incidence of lymphomas in 371 CAF1 mice injected with BALB/c spleen cells was compared with that in 324 control CAF1 mice. A high incidence of lymphomas was found in the treated mice, but not in the control animals. The development of the neoplasms was a function of the number of parental cells administered. Analyses of the injected mice for the presence of donor cells indicated that the majority of the injected parental cells lost antihost activity, probably within 24 hr of their administration. The tumors were of host origin, as judged by transplantation tests and antigenic analysis of tumor cells.

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Selected References

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  1. BINHAMMER R. T., FINERTY J. C., SCHNEIDER M., CUNNINGHAM A. W. Tumor induction in rats by single total-body x-irradiation. Radiat Res. 1957 Mar;6(3):339–348. [PubMed] [Google Scholar]
  2. Balls M., Ruben L. N. The induction of lymphosarcoma in Xenopus laevis by cancerous and normal tissues of Rana pipiens. Ann N Y Acad Sci. 1965 Aug 10;126(1):274–288. doi: 10.1111/j.1749-6632.1965.tb14280.x. [DOI] [PubMed] [Google Scholar]
  3. CUDKOWICZ G., STIMPFLING J. H. HYBRID RESISTANCE TO PARENTAL MARROW GRAFTS: ASSOCIATION WITH THE K REGION OF H-2. Science. 1964 Jun 12;144(3624):1339–1340. doi: 10.1126/science.144.3624.1339. [DOI] [PubMed] [Google Scholar]
  4. DUNN T. B. Normal and pathologic anatomy of the reticular tissue in laboratory mice, with a classification and discussion of neoplasms. J Natl Cancer Inst. 1954 Jun;14(6):1281–1433. [PubMed] [Google Scholar]
  5. Deringer M. K. Occurrence of mammary tumors, reticular neoplasms, and pulmonary tumors in strain BALB-cAnDe breeding female mice. J Natl Cancer Inst. 1965 Dec;35(6):1047–1052. [PubMed] [Google Scholar]
  6. East J., Branca M. Autoimmune reactions and malignant changes in germ-free New Zealand Black mice. Clin Exp Immunol. 1969 Jun;4(6):621–635. [PMC free article] [PubMed] [Google Scholar]
  7. East J. Immunopathology and neoplasms in New Zealand black (NZB) and SJL-J mice. Prog Exp Tumor Res. 1970;13:84–134. doi: 10.1159/000386038. [DOI] [PubMed] [Google Scholar]
  8. HOWARD J. G., MICHIE D., SIMONSEN M. Splenomegaly as a host response in graft-versus-host disease. Br J Exp Pathol. 1961 Oct;42:478–485. [PMC free article] [PubMed] [Google Scholar]
  9. Kaliss N. Micromethod for assaying immune cytolysis by the release of 51Cr. Transplantation. 1969 Oct;8(4):526–530. doi: 10.1097/00007890-196910000-00047. [DOI] [PubMed] [Google Scholar]
  10. Keast D., Stanley N. F. The induction of murine neoplasia. Pathology. 1969 Jan;1(1):19–26. doi: 10.3109/00313026909061031. [DOI] [PubMed] [Google Scholar]
  11. Keast D. The murine runting syndrome and neoplasia. Immunology. 1969 Jun;16(6):693–697. [PMC free article] [PubMed] [Google Scholar]
  12. Lambert P. H., Dixon F. J. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968 Mar 1;127(3):507–522. doi: 10.1084/jem.127.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lewis R. M., Armstrong M. Y., André-Schwartz J., Muftuoglu A., Beldotti L., Schwartz R. S. Chronic allogeneic disease. I. Development of glomerulonephritis. J Exp Med. 1968 Oct 1;128(4):653–679. doi: 10.1084/jem.128.4.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. METCALF D. Reticular tumours in mice subjected to prolonged antigenic stimulation. Br J Cancer. 1961 Dec;15:769–779. doi: 10.1038/bjc.1961.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. METCALF D. THE FATE OF PARENTAL PRELEUKEMIC CELLS IN LEUKEMIA-SUSCEPTIBLE AND LEUKEMIA-RESISTANT F1 HYBRID MICE. Cancer Res. 1963 Dec;23:1774–1781. [PubMed] [Google Scholar]
  16. Mellors R. C., Aoki T., Huebner R. J. Further implication of murine leukemia-like virs in the disorders of NZB mice. J Exp Med. 1969 May 1;129(5):1045–1062. doi: 10.1084/jem.129.5.1045. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Myburgh J. A. Repeated parabiosis in mice: immunological and haematological sequelae, and demonstration of a hybrid-anti-parent reaction. Transplantation. 1968 May;6(3):400–410. [PubMed] [Google Scholar]
  18. Parrott D. V., De Sousa M. A., East J. Thymus-dependent areas in the lymphoid organs of neonatally thymectomized mice. J Exp Med. 1966 Jan 1;123(1):191–204. doi: 10.1084/jem.123.1.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. SIMONSEN M., ENGELBRETH-HOLM J., JENSEN E., POULSEN H. A study of the graft-versus-host reaction in transplantation to embryos, F1 hybrids, and irradiated animals. Ann N Y Acad Sci. 1958 Oct 7;73(3):834–841. doi: 10.1111/j.1749-6632.1959.tb40863.x. [DOI] [PubMed] [Google Scholar]
  20. SIMONSEN M. Graft versus host reactions. Their natural history, and applicability as tools of research. Prog Allergy. 1962;6:349–467. [PubMed] [Google Scholar]
  21. STASTNY P., STEMBRIDGE V. A., ZIFF M. HOMOLOGOUS DISEASE IN THE ADULT RAT, A MODEL FOR AUTOIMMUNE DISEASE. I. GENERAL FEATURES AND CUTANEOUS LESIONS. J Exp Med. 1963 Oct 1;118:635–648. doi: 10.1084/jem.118.4.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Schwartz R. S., André-Schwartz J. Malignant lymphoproliferative diseases: interactions between immunological abnormalities and oncogenic viruses. Annu Rev Med. 1968;19:269–282. doi: 10.1146/annurev.me.19.020168.001413. [DOI] [PubMed] [Google Scholar]
  23. Schwartz R. S., Beldotti L. Malignant lymphomas following allogenic disease: transition from an immunological to a neoplastic disorder. Science. 1965 Sep 24;149(3691):1511–1514. doi: 10.1126/science.149.3691.1511. [DOI] [PubMed] [Google Scholar]
  24. Stastny P., Stembridge V. A., Vischer T., Ziff M. Homologous disease in the adult rat, a model for autoimmune disease. II. Findings in the joints, heart, and other tissues. J Exp Med. 1965 Oct 1;122(4):681–692. doi: 10.1084/jem.122.4.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. VENABLE J. H., COGGESHALL R. A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY. J Cell Biol. 1965 May;25:407–408. doi: 10.1083/jcb.25.2.407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. WIGZELL H. QUANTITATIVE TITRATIONS OF MOUSE H-2 ANTIBODIES USING CR-51-LABELLED TARGET CELLS. Transplantation. 1965 May;3:423–431. doi: 10.1097/00007890-196505000-00011. [DOI] [PubMed] [Google Scholar]
  27. Walford R. L., Hildemann W. H. Life span and lymphoma-incidence of mice injected at birth with spleen cells across a weak histocompatibility locus. Am J Pathol. 1965 Nov;47(5):713–721. [PMC free article] [PubMed] [Google Scholar]

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