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. 1970 May 1;131(5):881–893. doi: 10.1084/jem.131.5.881

HISTOCOMPATIBILITY STUDIES IN A CLOSELY BRED COLONY OF DOGS

I. INFLUENCE OF LEUKOCYTE GROUP ANTIGENS UPON RENAL ALLOGRAFT SURVIVAL IN THE UNMODIFIED HOST

F T Rapaport 1, T Hanaoka 1, T Shimada 1, F D Cannon 1, J W Ferrebee 1
PMCID: PMC2138831  PMID: 4910142

Abstract

The establishment of a closely bred colony of beagles with known leukocyte group phenotypes has permitted an assessment of the role of leukocyte group antigens in conditioning the survival of renal allografts in the unmodified host. 22 kidney transplants obtained from leukocyte group-compatible donors were accorded a mean survival time of 25.5 days, as compared with 13.1 days for 27 transplants obtained from incompatible donors. Donor-recipient coefficients of correlation and Swisher erythrocyte group incompatibilities did not appear to affect the observed results. The mean survival time of 21 renal allografts performed in randomly selected mongrel dogs was 9.5 days. Availability of a carefully characterized and phenotyped canine population may be useful in further studies of the comparative immunogenicity of the major transplantable organs, and of methods designed to facilitate prolonged organ transplant survival in the mammalian host.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALTMAN B. HEMAGGLUTININ IN SKIN AND KIDNEY HOMOTRANSPLANTATION IN DOGS. Transplantation. 1965 May;3:326–342. doi: 10.1097/00007890-196505000-00003. [DOI] [PubMed] [Google Scholar]
  2. Amos D. B., Hattler B. G., Hutchin P., McCloskey R., Zmijewski C. M. Skin donor selection by leucocyte typing. Lancet. 1966 Feb 5;1(7432):300–302. doi: 10.1016/s0140-6736(66)90646-5. [DOI] [PubMed] [Google Scholar]
  3. Bach F. H., Amos D. B. Hu-1: Major histocompatibility locus in man. Science. 1967 Jun 16;156(3781):1506–1508. doi: 10.1126/science.156.3781.1506. [DOI] [PubMed] [Google Scholar]
  4. Colombani J., Dausset J. L'histocompatibilité humaine. Pathol Biol (Paris) 1969 Mar;17(5):281–299. [PubMed] [Google Scholar]
  5. DAUSSET J. Iso-leuco-anticorps. Acta Haematol. 1958 Jul-Oct;20(1-4):156–166. doi: 10.1159/000205478. [DOI] [PubMed] [Google Scholar]
  6. Dausset J., Colombani J., Colombani M., Legrand L., Feingold N. Un nouvel antigène du système HL-A (Hu-1): l'antigène 15, allèle possible des antigènes 1, 11, 12. Nouv Rev Fr Hematol. 1968 May-Jun;8(3):398–406. [PubMed] [Google Scholar]
  7. Dausset J., Colombani J., Legrand L., Feingold N. Les sub-loci du système HL-A. Le système principal d'histocompatibilité de l'homme. Presse Med. 1969 May 10;77(23):849–852. [PubMed] [Google Scholar]
  8. Dausset J., Rapaport F. T. Histocompatibility studies in haploidentical genetic combinations. Transplant Proc. 1969 Mar;1(1):649–658. [PubMed] [Google Scholar]
  9. Dausset J., Walford R. L., Colombani J., Legrand L., Feingold N., Barge A., Rapaport F. T. The HL-A system sub-loci and their importance in transplantation. Transplant Proc. 1969 Mar;1(1):331–338. [PubMed] [Google Scholar]
  10. Epstein R. B., Storb R., Ragde H., Thomas E. D. Cytotoxic typing antisera for marrow grafting in littermate dogs. Transplantation. 1968 Jan;6(1):45–58. doi: 10.1097/00007890-196801000-00005. [DOI] [PubMed] [Google Scholar]
  11. HIRSCHHORN K., BACH F., RAPAPORT F. T., CONVERSE J. M., LAWRENCE H. S. THE RELATIONSHIP OF IN VITRO LYMPHOCYTE COMPATIBILITY TO HOMOGRAFT SENSITIVITY IN MAN. Ann N Y Acad Sci. 1964 Nov 30;120:303–306. doi: 10.1111/j.1749-6632.1964.tb34729.x. [DOI] [PubMed] [Google Scholar]
  12. LAWRENCE H. S. Homograft sensitivity. An expression of the immunologic origins and consequences of individuality. Physiol Rev. 1959 Oct;39:811–859. doi: 10.1152/physrev.1959.39.4.811. [DOI] [PubMed] [Google Scholar]
  13. Mollen N., Cannon F. D., Ferrebee J. W., St John D. Lymphocyte typing in allografted beagles. Transplantation. 1968 Nov;6(8):939–940. doi: 10.1097/00007890-196811000-00009. [DOI] [PubMed] [Google Scholar]
  14. RAMSEIER H., STREILEIN J. W. HOMOGRAFT SENSITIVITY REACTIONS IN IRRADIATED HAMSTERS. Lancet. 1965 Mar 20;1(7386):622–624. doi: 10.1016/s0140-6736(65)91713-7. [DOI] [PubMed] [Google Scholar]
  15. RAPAPORT F. T., LAWRENCE H. S., THOMAS L., CONVERSE J. M., TILLETT W. S., MULHOLLAND J. H. Cross-reactions to skin homografts in man. J Clin Invest. 1962 Dec;41:2166–2172. doi: 10.1172/JCI104675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. RAPAPORT F. T., THOMAS L., CONVERSE J. M., LAWRENCE H. S. The specificity of skin homograft rejection in man. Ann N Y Acad Sci. 1960 May 31;87:217–222. doi: 10.1111/j.1749-6632.1960.tb23195.x. [DOI] [PubMed] [Google Scholar]
  17. Rapaport F. T., Markowitz A. S., McCluskey R. T., Hanaoka T. Induction of glomerulonephritis in renal autografts. Surgery. 1969 Jul;66(1):34–41. [PubMed] [Google Scholar]
  18. Rubinstein P., Morgado F., Blumenstock D. A., Ferrebee J. W. Isohemagglutinins and histocompatibility in the dog. Transplantation. 1968 Dec;6(9):961–969. doi: 10.1097/00007890-196812000-00001. [DOI] [PubMed] [Google Scholar]
  19. SWISHER S. N., YOUNG L. E. The blood grouping systems of dogs. Physiol Rev. 1961 Jul;41:495–520. doi: 10.1152/physrev.1961.41.3.495. [DOI] [PubMed] [Google Scholar]
  20. Sakai A., Simonsen M., Jensen E. Kidney transplantation in siblings. Is immunosuppressive treatment invariably needed? Transplantation. 1969 May;7(5):444–446. [PubMed] [Google Scholar]
  21. Storb R., Epstein R. B., Bryant J., Ragde H., Thomas E. D. Marrow grafts by combined marrow and leukocyte infusions in unrelated dogs selected by histocompatibility typing. Transplantation. 1968 Jul;6(4):587–593. doi: 10.1097/00007890-196807000-00011. [DOI] [PubMed] [Google Scholar]
  22. THOMAS E. D., FERREBEE J. W. Transplanation of marrow and whole organs: experiences and comments. Can Med Assoc J. 1962 Mar 10;86:435–444. [PMC free article] [PubMed] [Google Scholar]
  23. WILSON R. E., HENRY L., MERRILL J. P. A MODEL SYSTEM FOR DETERMINING HISTOCOMPATIBILITY IN MAN. J Clin Invest. 1963 Sep;42:1497–1503. doi: 10.1172/JCI104834. [DOI] [PMC free article] [PubMed] [Google Scholar]

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