Abstract
Rabbits were induced to form atheromatous cardiovascular lesions by subjecting them to treatments of a single BSA injection plus a 2-wk period of cholesterol diet, or to the diet alone. Microscopic examination of the hearts at the end of the 2-wk induction period, or after having been returned to regular diet for 5 or 8 wk, showed that lesion incidence in the cholesterol-only animall decreased markedly during the 8-wk rest period, while little change in incidence occurred in animals with lesions from the combined treatment. This finding was taken to mean that the latter type of lesion was less reversible, and therefore perhaps more pathologically significant, than the former type. It was felt that lipid deposition was not solely responsible for this prolongation, since it was present in diet-only lesions which disappeared with time, and also seemed to be disappearing from the prolonged lesions in all treatment groups. On the other hand, elastic tissue was demonstrated only in lesions arising from the combined treatment, and it is hypothesized that this feature is implicated in the prolongation of these lesions.
Full Text
The Full Text of this article is available as a PDF (566.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bortz W. M. Reversibility of atherosclerosis in cholesterol-fed rabbits. Circ Res. 1968 Feb;22(2):135–139. doi: 10.1161/01.res.22.2.135. [DOI] [PubMed] [Google Scholar]
- GERMUTH F. G., Jr A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type. J Exp Med. 1953 Feb 1;97(2):257–282. doi: 10.1084/jem.97.2.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gillman T. On the possible roles of arterial growth, remodeling, repair, and involution in the genesis of arterial degeneration. Ann N Y Acad Sci. 1968 Nov 21;149(2):731–751. doi: 10.1111/j.1749-6632.1968.tb53832.x. [DOI] [PubMed] [Google Scholar]
- Minick C. R., Murphy G. E., Campbell W. G., Jr Experimental induction of athero-arteriosclerosis by the synergy of allergic injury to arteries and lipid-rich diet. I. Effect of repeated injections of horse serum in rabbits fed a dietary cholesterol supplement. J Exp Med. 1966 Oct 1;124(4):635–652. doi: 10.1084/jem.124.4.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Van Winkle M., Levy L. Effect of removal of cholesterol diet upon serum sickness-cholesterol-induced atherosclerosis. J Exp Med. 1968 Sep 1;128(3):497–515. doi: 10.1084/jem.128.3.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wissler R. W., Vesselinovitch D. Experimental models of human atherosclerosis. Ann N Y Acad Sci. 1968 Nov 21;149(2):907–922. [PubMed] [Google Scholar]