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. 1971 Jan 1;133(1):113–132. doi: 10.1084/jem.133.1.113

WILD-TYPE GROSS LEUKEMIA VIRUS AND THE PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NEW ZEALAND MICE

Robert C Mellors 1, Toshikazu Shirai 1, Tadao Aoki 1, Robert J Huebner 1, Krzysztof Krawczynski 1
PMCID: PMC2138888  PMID: 4924198

Abstract

The pathogenesis of the spontaneous glomerulonephritis of NZB and (NZB x NZW) F1 hybrid mice is related at least in part to the formation of natural antibody against antigens of the G (Gross) system, and apparently to the deposition in the glomeruli of immune complexes of G natural antibody with G soluble antigen (GSA), type-specific antigen specified by wild-type Gross leukemia virus. G natural antibody and GSA are detectable in the acid-buffer eluate of the kidneys of NZB mice during the course of the glomerulonephritis. (NZB x NZW) F1 hybrid mice develop glomerulonephritis and produce GSA and free G natural antibody earlier in life than do NZB mice. The proteinuria manifestation of the gomerulonephritis of (NZB x NZW) F1 hybrid mice becomes increasingly prevalent as GSA undergoes immune elimination from the circulation. Gross leukemia virus-specified antigens together with bound immunoglobulins are located in the glomerular lesions of (NZB x NZW) F1 hybrid mice, both in the mesangium as observed in NZB mice and also in the wall of the peripheral capillary loops of the glomeruli.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AARONS I. RENAL IMMUNOFLUORESCENCE IN NZB-NZW MICE. Nature. 1964 Sep 5;203:1080–1081. doi: 10.1038/2031080a0. [DOI] [PubMed] [Google Scholar]
  2. Aoki T., Boyse E. A., Old L. J., De Harven E., Hämmerling U., Wood H. A. G (Gross) and H-2 cell-surface antigens: location on Gross leukemia cells by electron microscopy with visually labeled antibody. Proc Natl Acad Sci U S A. 1970 Mar;65(3):569–576. doi: 10.1073/pnas.65.3.569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Aoki T., Boyse E. A., Old L. J. Occurrence of natural antibody to the G (gross) leukemia antigen in mice. Cancer Res. 1966 Jul;26(7):1415–1419. [PubMed] [Google Scholar]
  4. Aoki T., Boyse E. A., Old L. J. Wild-type Gross leukemia virus. I. Soluble antigen (GSA) in the plasma and tissues of infected mice. J Natl Cancer Inst. 1968 Jul;41(1):89–96. [PubMed] [Google Scholar]
  5. Dunn T. B., Green A. W. Morphology of BALB/c mice inoculated with Rauscher virus. J Natl Cancer Inst. 1966 Jun;36(6):987–1001. [PubMed] [Google Scholar]
  6. East J., Prosser P. R., Holborow E. J., Jaquet H. Autoimmune reactions and virus-like particles in germ-free NZB mice. Lancet. 1967 Apr 8;1(7493):755–757. doi: 10.1016/s0140-6736(67)91368-2. [DOI] [PubMed] [Google Scholar]
  7. East J., de Sousa M. A., Parrott D. M. Immunopathology of New Zealand black (NZB) mice. Transplantation. 1965 Nov;3(6):711–729. doi: 10.1097/00007890-196511000-00003. [DOI] [PubMed] [Google Scholar]
  8. Geering G., Old L. J., Boyse E. A. Antigens of leukemias induced by naturally occurring murine leukemia virus: their relation to the antigens of gross virus and other murine leukemia viruses. J Exp Med. 1966 Oct 1;124(4):753–772. doi: 10.1084/jem.124.4.753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. HELYER B. J., HOWIE J. B. Renal disease associated with positive lupus erythematosus tests in a cross-bred strain of mice. Nature. 1963 Jan 12;197:197–197. doi: 10.1038/197197a0. [DOI] [PubMed] [Google Scholar]
  10. HELYER B. J., HOWIE J. B. Spontaneous auto-immune disease in NZB/BL mice. Br J Haematol. 1963 Apr;9:119–131. doi: 10.1111/j.1365-2141.1963.tb05450.x. [DOI] [PubMed] [Google Scholar]
  11. HOLMES M. C., BURNET F. M. THE NATURAL HISTORY OF AUTOIMMUNE DISEASE IN NZB MICE. A COMPARISON WITH THE PATTERN OF HUMAN AUTOIMMUNE MANIFESTATIONS. Ann Intern Med. 1963 Sep;59:265–276. doi: 10.7326/0003-4819-59-3-265. [DOI] [PubMed] [Google Scholar]
  12. Hartley J. W., Rowe W. P., Capps W. I., Huebner R. J. Complement fixation and tissue culture assays for mouse leukemia viruses. Proc Natl Acad Sci U S A. 1965 May;53(5):931–938. doi: 10.1073/pnas.53.5.931. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hirsch M. S., Allison A. C., Harvey J. J. Immune complexes in mice infected neonatally with Moloney leukaemogenic and murine sarcoma viruses. Nature. 1969 Aug 16;223(5207):739–740. doi: 10.1038/223739a0. [DOI] [PubMed] [Google Scholar]
  14. Hollmann K. H., Verley J. M. Présence de particules virales dans les organes de la souris NZB. C R Acad Sci Hebd Seances Acad Sci D. 1967 Feb 6;264(6):871–873. [PubMed] [Google Scholar]
  15. Howie J. B., Helyer B. J. Autoimmune disease in mice. Ann N Y Acad Sci. 1965 Jun 30;124(1):167–177. doi: 10.1111/j.1749-6632.1965.tb18955.x. [DOI] [PubMed] [Google Scholar]
  16. Howie J. B., Helyer B. J. The immunology and pathology of NZB mice. Adv Immunol. 1968;9:215–266. doi: 10.1016/s0065-2776(08)60444-7. [DOI] [PubMed] [Google Scholar]
  17. Huebner R. J., Todaro G. J. Oncogenes of RNA tumor viruses as determinants of cancer. Proc Natl Acad Sci U S A. 1969 Nov;64(3):1087–1094. doi: 10.1073/pnas.64.3.1087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Koffler D., Schur P. H., Kunkel H. G. Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med. 1967 Oct 1;126(4):607–624. doi: 10.1084/jem.126.4.607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Lambert P. H., Dixon F. J. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968 Mar 1;127(3):507–522. doi: 10.1084/jem.127.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. MELLORS R. C. AUTOIMMUNE DISEASE IN NZB/BL MICE. I. PATHOLOGY AND PATHOGENESIS OF A MODEL SYSTEM OF SPONTANEOUS GLOMERULONEPHRITIS. J Exp Med. 1965 Jul 1;122:25–40. doi: 10.1084/jem.122.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  22. Mellors R. C., Aoki T., Huebner R. J. Further implication of murine leukemia-like virs in the disorders of NZB mice. J Exp Med. 1969 May 1;129(5):1045–1062. doi: 10.1084/jem.129.5.1045. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Mellors R. C. Autoimmune and immunoproliferative diseases of NZB/Bl mice and hybrids. Int Rev Exp Pathol. 1966;5:217–252. [PubMed] [Google Scholar]
  24. Mellors R. C. Autoimmune disease in NZB-Bl mice. II. Autoimmunity and malignant lymphoma. Blood. 1966 Apr;27(4):435–448. [PubMed] [Google Scholar]
  25. Mellors R. C., Huang C. Y. Immunopathology of NZB/BL mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy. J Exp Med. 1966 Dec 1;124(6):1031–1038. doi: 10.1084/jem.124.6.1031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Mellors R. C., Huang C. Y. Immunopathology of NZB/BL mice. VI. Virus separable from spleen and pathogenic for Swiss mice. J Exp Med. 1967 Jul 1;126(1):53–62. doi: 10.1084/jem.126.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Miller D. G. The association of immune disease and malignant lymphoma. Ann Intern Med. 1967 Mar;66(3):507–521. doi: 10.7326/0003-4819-66-3-507. [DOI] [PubMed] [Google Scholar]
  28. Moloney J. B. A virus-induced rhabdomyosarcoma of mice. Natl Cancer Inst Monogr. 1966 Sep;22:139–142. [PubMed] [Google Scholar]
  29. Old L. J., Boyse E. A., Stockert E. The G (Gross) leukemia antigen. Cancer Res. 1965 Jul;25(6):813–819. [PubMed] [Google Scholar]
  30. Prosser P. R. Particles resembling murine leukaemia virus in New Zealand black mice. Clin Exp Immunol. 1968 Mar;3(3):213–226. [PMC free article] [PubMed] [Google Scholar]
  31. Recher L., Tanaka T., Sykes J. A., Yumoto T., Seman G., Young L., Dmochowski L. Further studies on the biological relationship of murine leukemia viruses and on kidney lesions of mice with leukemia induced by these viruses. Natl Cancer Inst Monogr. 1966 Sep;22:459–479. [PubMed] [Google Scholar]
  32. SCHEIDEGGER J. J. Une micro-méthode de l'immuno-electrophorèse. Int Arch Allergy Appl Immunol. 1955;7(2):103–110. [PubMed] [Google Scholar]
  33. Talal N., Sokoloff L., Barth W. F. Extrasalivary lymphoid abnormalities in Sjögren's syndrome (reticulum cell sarcoma, "pseudolymphoma," macroglobulinemia). Am J Med. 1967 Jul;43(1):50–65. doi: 10.1016/0002-9343(67)90148-9. [DOI] [PubMed] [Google Scholar]

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