Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1971 Jan 31;133(2):400–409. doi: 10.1084/jem.133.2.400

THE MEDIATOR OF CELLULAR IMMUNITY

II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES

F T Koster 1, D D McGregor 1, G B Mackaness 1
PMCID: PMC2138894  PMID: 5002522

Abstract

Peritoneal exudates from rats which have survived an infection with L. monocytogenes can protect cyclophosphamide-treated recipients against a Listeria challenge. They are more effective in this respect than cells obtained from the spleen or thoracic duct lymph. Since exudate cells from normal rats and inocula prepared from the resident peritoneal cell populations of infected donors are unable to inhibit the challenge infection, the protective cells must belong to a class of lymphocytes that emerges from the blood in response to inflammation. It is significant therefore that thoracic duct lymphocytes formed during an acute Listeria infection can move into exudates induced by a variety of inflammatory stimuli. The affinity of newly formed lymphocytes for inflamed tissue points to a mechanism whereby the host marshalls its cellular defenses at sites of bacterial invasion. The tendency of short-lived lymphocytes to leave inflamed vessels might also explain their short-circulating life-span.

Full Text

The Full Text of this article is available as a PDF (532.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cohen S., McCluskey R. T., Benacerraf B. Studies on the specificity of the cellular infiltrate of delayed hypersensitivity reactions. J Immunol. 1967 Feb;98(2):269–273. [PubMed] [Google Scholar]
  2. David J. R. Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci U S A. 1966 Jul;56(1):72–77. doi: 10.1073/pnas.56.1.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hill W. C. The influence of the cellular infiltrate on the evolution and intensity of delayed hypersensitivity reactions. J Exp Med. 1969 Feb 1;129(2):363–370. doi: 10.1084/jem.129.2.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. KAY K., RIEKE W. O. Tuberculin hypersensitivity: studies with radioactive antigen and mononuclear cells. Science. 1963 Feb 8;139(3554):487–490. doi: 10.1126/science.139.3554.487. [DOI] [PubMed] [Google Scholar]
  5. Koster F., McGregor D. D. Rat thoracic duct lymphocytes: types that participate in inflammation. Science. 1970 Feb 20;167(3921):1137–1139. doi: 10.1126/science.167.3921.1137. [DOI] [PubMed] [Google Scholar]
  6. MCCLUSKEY R. T., BENACERRAF B., MCCLUSKEY J. W. STUDIES ON THE SPECIFICITY OF THE CELLULAR INFILTRATE IN DELAYED HYPERSENSITIVITY REACTIONS. J Immunol. 1963 Mar;90:466–477. [PubMed] [Google Scholar]
  7. MORGAN J. F., MORTON H. J., PARKER R. C. Nutrition of animal cells in tissue culture; initial studies on a synthetic medium. Proc Soc Exp Biol Med. 1950 Jan;73(1):1–8. doi: 10.3181/00379727-73-17557. [DOI] [PubMed] [Google Scholar]
  8. Mackaness G. B. The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med. 1969 May 1;129(5):973–992. doi: 10.1084/jem.129.5.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mackaness G. B. The monocyte in cellular immunity. Semin Hematol. 1970 Apr;7(2):172–184. [PubMed] [Google Scholar]
  10. McGregor D. D., Koster F. T., Mackaness G. B. The mediator of cellular immunity. I. The life-span and circulation dynamics of the immunologically committed lymphocyte. J Exp Med. 1971 Feb 1;133(2):389–399. doi: 10.1084/jem.133.2.389. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. PRENDERGAST R. A. CELLULAR SPECIFICITY IN THE HOMOGRAFT REACTION. J Exp Med. 1964 Mar 1;119:377–388. doi: 10.1084/jem.119.3.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. ROBINSON S. H., BRECHER G., LOURIE I. S., HALEY J. E. LEUKOCYTE LABELING IN RATS DURING AND AFTER CONTINUOUS INFUSION OF TRITIATED THYMIDINE: IMPLICATIONS FOR LYMPHOCYTE LONGEVITY AND DNA REUTILIZATION. Blood. 1965 Sep;26:281–295. [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES