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. 1971 Jan 31;133(2):260–274. doi: 10.1084/jem.133.2.260

HISTOCOMPATIBILITY STUDIES IN A CLOSELY BRED COLONY OF DOGS

II. INFLUENCE OF THE DL-A SYSTEM OF CANINE HISTOCOMPATIBILITY UPON THE SURVIVAL OF CARDIAC ALLOGRAFTS

Felix T Rapaport 1, Arthur D Boyd 1, Frank C Spencer 1, Richard R Lower 1, Jean Dausset 1, Florence D Cannon 1, Joseph W Ferrebee 1
PMCID: PMC2138901  PMID: 4943931

Abstract

The DL-A system of histocompatibility plays an important role in conditioning the survival of cardiac allografts in the unmodified canine host. The mean survival time of six cardiac allografts performed in DL-A-compatible littermate dogs obtained from a closely bred colony of beagles was 53.2 days, while the MST of transplants performed in seven DL-A-incompatible animals was 7.3 days. The MST of cardiac allografts performed in nine DL-A-compatible nonlittermate beagles was 26.3 days, as compared with 6.3 days in six DL-A-incompatible nonlittermate transplants. The results did not appear to be affected by Swisher erythrocyte-group incompatibilities. The MST of 28 cardiac allografts performed in randomly selected mongrel dogs was 10.0 days. Incompatibilities for DL-A antigens e, f, g, l, and m may constitute major barriers to transplantation, but antigens b, c, d, and k appeared to act as weak histocompatibility antigens. Under controlled conditions of donor-recipient DL-A compatibility, cardiac allografts may be less immunogenic than renal transplants. Heart transplants performed across major donor-recipient DL-A incompatibilities appeared, however, to be more vulnerable to the events of allograft rejection than renal allografts performed under similar conditions. The selection of optimally compatible donor-recipient combinations for organ transplantation may be aided materially by genetic studies of the transmission of DL-A antigens to the animals under consideration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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