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. 1971 May 1;133(5):1004–1014. doi: 10.1084/jem.133.5.1004

EVIDENCE FOR RECENT DUPLICATIONS AMONG CERTAIN GAMMA GLOBULIN HEAVY CHAIN GENES

J B Natvig 1, T E Michaelsen 1, H G Kunkel 1
PMCID: PMC2138913  PMID: 4101803

Abstract

A survey of a large number of human sera with the heavy chain genetic markers of the γ-globulin system has revealed an unusual gene complex which is inherited as a unit through two different families. The gene complex involves two pairs of γG1 genetic markers which ordinarily behave as homoalleles, Gm z and Gm f for the Fd part of γG1 molecules, and Gm a and non-a for the Fc part. Isolation of the γG1 fraction from the unusual sera demonstrated the presence of the important non-a antigen in the γG1 fraction. Through the use of immunoadsorbents it was shown that these antigens were not part of a single molecule but that separate molecules were involved. The accumulated evidence indicated that the appearance of such homoalleles on the same chromosome probably resulted from a recent gene duplication, giving rise to two γG1 cistrons on one chromosome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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