Abstract
Sheep erythrocytes ingested by guinea pig peritoneal macrophages in vitro, and permitted to undergo digestion for various periods, were found after some hours to lose the capacity to induce antibodies while gaining the ability to invoke delayed hypersensitivity. These observations may be related to the known predilection of small molecular immunogens to act as good inducers of delayed reactivity and poor stimulators of antibody. They may be related also to the activity of mycobacterial adjuvant as a vehicle for the induction of delayed hypersensitivity on the basis that this melange activates macrophages to phagocytose and enzymatically degrade macromolecular antigens rapidly. The thesis that small fragments of antigenic molecules may preferentially invoke hypersensitivity can be interpreted on the basis of current concepts of multicellular involvements in immune responses.
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Selected References
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- Argyris B. F. Role of macrophages in antibody production. Immune response to sheep red blood cells. J Immunol. 1967 Oct;99(4):744–750. [PubMed] [Google Scholar]
- BENACERRAF B., GELL P. G. Studies on hypersensitivity. I. Delayed and Arthustype skin reactivity to protein conjugates in guinea pigs. Immunology. 1959 Jan;2(1):53–63. [PMC free article] [PubMed] [Google Scholar]
- BOYDEN S. V. CYTOPHILIC ANTIBODY IN GUINEA-PIGS WITH DELAYED-TYPE HYPERSENSITIVITY. Immunology. 1964 Jul;7:474–483. [PMC free article] [PubMed] [Google Scholar]
- COHN Z. A. THE FATE OF BACTERIA WITHIN PHAGOCYTIC CELLS. 3. DESTRUCTION OF AN ESCHERICHIA COLI AGGLUTINOGEN WITHIN POLYMORPHONUCLEAR LEUCOCYTES AND MACROPHAGES. J Exp Med. 1964 Nov 1;120:869–883. doi: 10.1084/jem.120.5.869. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COHN Z. A., WIENER E. THE PARTICULATE HYDROLASES OF MACROPHAGES. I. COMPARATIVE ENZYMOLOGY, ISOLATION, AND PROPERTIES. J Exp Med. 1963 Dec 1;118:991–1008. doi: 10.1084/jem.118.6.991. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Claman H. N., Chaperon E. A. Immunologic complementation between thymus and marrow cells--a model for the two-cell theory of immunocompetence. Transplant Rev. 1969;1:92–113. doi: 10.1111/j.1600-065x.1969.tb00137.x. [DOI] [PubMed] [Google Scholar]
- Dannenberg A. M., Jr Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes. Bacteriol Rev. 1968 Jun;32(2):85–102. doi: 10.1128/br.32.2.85-102.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- EISEN H. N., BELMAM S. Studies of hypersensitivity to low molecular weight substances. II. Reactions of some allergenic substituted dinitrobenzenes with cysteine or cystine of skin proteins. J Exp Med. 1953 Dec;98(6):533–549. doi: 10.1084/jem.98.6.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ferraresi R. W., Dedrick C. T., Raffel S., Goihman-Yahr M. Studies of the macrophage inhibition test. I. Comparison of the skin and cell migration reactions during the course of development of delayed hypersensitivity. J Immunol. 1969 Apr;102(4):852–858. [PubMed] [Google Scholar]
- Gerety R. J., Ferraresi R. W., Raffel S. Polysaccharide in delayed hypersensitivity. I. Pneumococcal polysaccharide as inducer and elicitor of delayed reactivity in guinea pigs. J Exp Med. 1970 Jan 1;131(1):189–206. doi: 10.1084/jem.131.1.189. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones V. E., Leskowitz S. Role of the carrier in development of delayed sensitivity to the azophenyl-arsonate group. Nature. 1965 Aug 7;207(997):596–597. doi: 10.1038/207596a0. [DOI] [PubMed] [Google Scholar]
- MAURER P. H. Immunologic studies with ethylene oxide-treated human serum. J Exp Med. 1961 Jun 1;113:1029–1039. doi: 10.1084/jem.113.6.1029. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MESSINA V. P., ROSENBERG L. T. Enhancement by normal cells of an immunological response. Proc Soc Exp Biol Med. 1962 Aug-Sep;110:893–895. doi: 10.3181/00379727-110-27683. [DOI] [PubMed] [Google Scholar]
- Miller J. F., Mitchell G. F. Thymus and antigen-reactive cells. Transplant Rev. 1969;1:3–42. doi: 10.1111/j.1600-065x.1969.tb00135.x. [DOI] [PubMed] [Google Scholar]
- Mitchison N. A. The immunogenic capacity of antigen taken up by peritoneal exudate cells. Immunology. 1969 Jan;16(1):1–14. [PMC free article] [PubMed] [Google Scholar]
- Morita T., Perkins E. H. A simple quantitative method to assess the in vitro engulfing and degradative potentials of mouse peritoneal phagocytic cells. J Reticuloendothel Soc. 1965 Dec;2(5):406–419. [PubMed] [Google Scholar]
- Salvin S. B., Liauw H. L. Hypersensitivity to peptide fragments. Int Arch Allergy Appl Immunol. 1967;31(4):366–379. doi: 10.1159/000229882. [DOI] [PubMed] [Google Scholar]
- Stupp Y., Borek F., Sela M. Studies on the types of immune responses to synthetic antigens in guinea-pigs. Immunology. 1966 Dec;11(6):561–570. [PMC free article] [PubMed] [Google Scholar]
- Taylor R. B. Cellular cooperation in the antibody response of mice to two serum albumins: specific function of thymus cells. Transplant Rev. 1969;1:114–149. doi: 10.1111/j.1600-065x.1969.tb00138.x. [DOI] [PubMed] [Google Scholar]
- Unanue E. R., Askonas B. A. Persistence of immunogenicity of antigen after uptake by macrophages. J Exp Med. 1968 May 1;127(5):915–926. doi: 10.1084/jem.127.5.915. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Unanue E. R., Askonas B. A. The immune response of mice to antigen in macrophages. Immunology. 1968 Aug;15(2):287–296. [PMC free article] [PubMed] [Google Scholar]
- Unanue E. R. The immune response of mice to keyhole limpet hemocyanin bound to macrophages. J Immunol. 1969 Apr;102(4):893–898. [PubMed] [Google Scholar]
- Williams R. M., Waksman B. H. Thymus-derived cells in the early phase of delayed tuberculin reactions. J Immunol. 1969 Dec;103(6):1435–1437. [PubMed] [Google Scholar]