Abstract
A substantial portion of the lymphocyte-like cells in induced peritoneal exudates derive from cells which enter the blood by way of the thoracic duct. The migrant cells have been identified as large and medium lymphocytes, but they may also include short-lived small lymphocytes derived from them. Small lymphocytes which have a potentially long circulating life-span are excluded from exudates, although cells of this type predominate in thoracic duct lymph. The results imply that many (perhaps all) of the small round cells in inflamed tissue are members of a line of rapidly proliferating lymphocytes. Specifically committed lymphocytes with precisely these properties are added to the blood of rats infected with Listeria monocytogenes. The localization of committed lymphocytes in inflammatory foci could be the crucial event which enables the host to focus his cellular defenses at sites of bacterial implantation.
Full Text
The Full Text of this article is available as a PDF (712.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CAFFREY R. W., RIEKE W. O., EVERETT N. B. Radioautographic studies of small lymphocytes in the thoracic duct of the rat. Acta Haematol. 1962;28:145–154. doi: 10.1159/000207257. [DOI] [PubMed] [Google Scholar]
- EVERETT N. B., CAFFREY R. W., RIEKE W. O. RECIRCULATION OF LYMPHOCYTES. Ann N Y Acad Sci. 1964 Feb 28;113:887–897. doi: 10.1111/j.1749-6632.1964.tb40710.x. [DOI] [PubMed] [Google Scholar]
- Everett N. B., Tyler R. W. Lymphopoiesis in the thymus and other tissues: functional implications. Int Rev Cytol. 1967;22:205–237. doi: 10.1016/s0074-7696(08)61836-7. [DOI] [PubMed] [Google Scholar]
- GOWANS J. L. The fate of parental strain small lymphocytes in F1 hybrid rats. Ann N Y Acad Sci. 1962 Oct 24;99:432–455. doi: 10.1111/j.1749-6632.1962.tb45326.x. [DOI] [PubMed] [Google Scholar]
- Griscelli C., Vassalli P., McCluskey R. T. The distribution of large dividing lymph node cells in syngeneic recipient rats after intravenous injection. J Exp Med. 1969 Dec 1;130(6):1427–1451. doi: 10.1084/jem.130.6.1427. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koster F. T., McGregor D. D., Mackaness G. B. The mediator of cellular immunity. II. Migration of immunologically committed lymphocytes into inflammatory exudates. J Exp Med. 1971 Feb 1;133(2):400–409. doi: 10.1084/jem.133.2.400. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koster F., McGregor D. D. Rat thoracic duct lymphocytes: types that participate in inflammation. Science. 1970 Feb 20;167(3921):1137–1139. doi: 10.1126/science.167.3921.1137. [DOI] [PubMed] [Google Scholar]
- MACKANESS G. B. Cellular resistance to infection. J Exp Med. 1962 Sep 1;116:381–406. doi: 10.1084/jem.116.3.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McGregor D. D., Koster F. T., Mackaness G. B. The mediator of cellular immunity. I. The life-span and circulation dynamics of the immunologically committed lymphocyte. J Exp Med. 1971 Feb 1;133(2):389–399. doi: 10.1084/jem.133.2.389. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McGregor D. D., Koster F. T., Mackaness G. B. The short lived small lymphocyte as a mediator of cellular immunity. Nature. 1970 Nov 28;228(5274):855–856. doi: 10.1038/228855a0. [DOI] [PubMed] [Google Scholar]
- WIENER J., SPIRO D., RUSSELL P. S. AN ELECTRON MICROSCOPIC STUDY OF THE HOMOGRAFT REACTION. Am J Pathol. 1964 Feb;44:319–347. [PMC free article] [PubMed] [Google Scholar]
- Wiener J., Spiro D., Zunker H. O. A cellular study of tuberculin sensitivity. Am J Pathol. 1965 Nov;47(5):723–763. [PMC free article] [PubMed] [Google Scholar]