Skip to main content
PMC home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1971 Oct 31;134(5):1083–1094. doi: 10.1084/jem.134.5.1083

CELLULAR RECEPTORS

EFFECT OF ANTI-ALLOANTISERUM ON THE RECOGNITION OF TRANSPLANTATION ANTIGENS

Hansruedy Ramseier 1, Jean Lindenmann 1
PMCID: PMC2139008  PMID: 4939368

Abstract

The possibility that a rat alloantiserum DA anti-Lewis possesses similar recognition structures for Lewis transplantation antigens, as do DA immunocompetent cells, was investigated by raising an antiserum against this alloantiserum in (Lewis x DA)F1 hosts. This antiserum, as well as one provoked by injecting DA lymphoid cells, was active against recognition structures for Lewis antigens of DA immunocompetent cells. The anti-(DA anti-Lewis) antiserum displayed the same degree of specificity as was found previously for anti-recognition structure sera prepared by injecting parental strain lymphoid cells into F1 hosts. Since the activities of antisera raised against cell-bound receptors or against the antigen-binding region of an immunoglobulin were indistinguishable, it was concluded that the functional part of cell-associated receptors might be structurally similar to the variable portion of an immunoglobulin.

Full Text

The Full Text of this article is available as a PDF (662.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMOS D. B., GORER P. A., MIKULSKA B. M., BILLINGHAM R. E., SPARROW E. M. An antibody response to skin homografts in mice. Br J Exp Pathol. 1954 Apr;35(2):203–208. [PMC free article] [PubMed] [Google Scholar]
  2. Byrt P., Ada G. L. An in vitro reaction between labelled flagellin or haemocyanin and lymphocyte-like cells from normal animals. Immunology. 1969 Oct;17(4):503–516. [PMC free article] [PubMed] [Google Scholar]
  3. ELKINS W. L. INVASION AND DESTRUCTION OF HOMOLOGOUS KIDNEY BY LOCALLY INOCULATED LYMPHOID CELLS. J Exp Med. 1964 Sep 1;120:329–348. doi: 10.1084/jem.120.3.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FOX M. Cytological estimation of proliferating donor cells during graft-versus-host disease in F1 hybrid mice injected with parental spleen cells. Immunology. 1962 Jul;5:489–495. [PMC free article] [PubMed] [Google Scholar]
  5. Greaves M. F. Biological effects of anti-immunoglobulins: evidence for immunoglobulin receptors on 'T' and 'B' lymphocytes. Transplant Rev. 1970;5:45–75. doi: 10.1111/j.1600-065x.1970.tb00356.x. [DOI] [PubMed] [Google Scholar]
  6. Kunkel H. G., Mannik M., Williams R. C. Individual Antigenic Specificity of Isolated Antibodies. Science. 1963 Jun 14;140(3572):1218–1219. doi: 10.1126/science.140.3572.1218. [DOI] [PubMed] [Google Scholar]
  7. Lesley J., Dutton R. W. Antigen receptor molecules: inhibition by antiserum against kappa light chains. Science. 1970 Jul 31;169(3944):487–488. doi: 10.1126/science.169.3944.487. [DOI] [PubMed] [Google Scholar]
  8. NOWELL P. C., DEFENDI V. DISTRIBUTION OF PROLIFERATING DONOR CELLS IN RUNT DISEASE IN RATS. Transplantation. 1964 May;2:375–382. doi: 10.1097/00007890-196405000-00006. [DOI] [PubMed] [Google Scholar]
  9. Oudin J. The genetic control of immunoglobulin synthesis. Proc R Soc Lond B Biol Sci. 1966 Nov 22;166(1003):207–221. doi: 10.1098/rspb.1966.0094. [DOI] [PubMed] [Google Scholar]
  10. Rabellino E., Colon S., Grey H. M., Unanue E. R. Immunoglobulins on the surface of lymphocytes. I. Distribution and quantitation. J Exp Med. 1971 Jan 1;133(1):156–167. doi: 10.1084/jem.133.1.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Raff M. C., Sternberg M., Taylor R. B. Immunoglobulin determinants on the surface of mouse lymphoid cells. Nature. 1970 Feb 7;225(5232):553–554. doi: 10.1038/225553a0. [DOI] [PubMed] [Google Scholar]
  12. Ramseier H., Lindenmann J. F1 hybrid animals: reactivity against recognition structures of parental strain lymphoid cells. Pathol Microbiol (Basel) 1969;34(6):379–387. doi: 10.1159/000162189. [DOI] [PubMed] [Google Scholar]
  13. Ramseier H., Palm J. Further studies of histocompatibility loci in rats. Transplantation. 1967 Jul;5(4):721–729. doi: 10.1097/00007890-196707000-00014. [DOI] [PubMed] [Google Scholar]
  14. Ramseier H. Quaitative studies on antigenic recognition. I. Immunological and nonimmunological parameters of the response. J Exp Med. 1969 Dec 1;130(6):1279–1294. doi: 10.1084/jem.130.6.1279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ramseier H. Quantitative studies on antigenic recognition. II. Kinetics of the recognition event. Eur J Immunol. 1971 Jun;1(3):171–180. doi: 10.1002/eji.1830010306. [DOI] [PubMed] [Google Scholar]
  16. SELL S., GELL P. G. STUDIES ON RABBIT LYMPHOCYTES IN VITRO. I. STIMULATION OF BLAST TRANSFORMATION WITH AN ANTIALLOTYPE SERUM. J Exp Med. 1965 Aug 1;122:423–440. doi: 10.1084/jem.122.2.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Siskind G. W., Benacerraf B. Cell selection by antigen in the immune response. Adv Immunol. 1969;10:1–50. doi: 10.1016/s0065-2776(08)60414-9. [DOI] [PubMed] [Google Scholar]
  18. Wigzell H., Andersson B. Cell separation on antigen-coated columns. Elimination of high rate antibody-forming cells and immunological memory cells. J Exp Med. 1969 Jan 1;129(1):23–36. doi: 10.1084/jem.129.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wigzell H., Mäkelä O. Separation of normal and immune lymphoid cells by antigen-coated coated columns. Antigen-binding characteristics of membrane antibodies as analyzed by hapten-protein antigens. J Exp Med. 1970 Jul 1;132(1):110–126. doi: 10.1084/jem.132.1.110. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. ZEISS I. M., FOX M. Donor and host contribution to splenomegaly in homologous mouse chimaeras. Nature. 1963 Feb 16;197:673–675. doi: 10.1038/197673a0. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES