Skip to main content
PMC home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1971 Oct 31;134(5):1335–1348. doi: 10.1084/jem.134.5.1335

H-2-LINKED GENETIC CONTROL OF IMMUNE RESPONSIVENESS TO OVALBUMIN AND OVOMUCOID

Nelson M Vaz 1, Julia M Phillips-Quagliata 1, Bernard B Levine 1, Eda M Vaz 1
PMCID: PMC2139015  PMID: 5112206

Abstract

Immune responsiveness of inbred mice to low doses of ovalbumin or ovomucoid is under control of single dominant genes closely linked to alleles of the H-2 locus. High responsiveness to ovomucoid is linked with the H-2a and H-2k alleles, and to ovalbumin with the H-2b, H-2d, and H-2q alleles.

Full Text

The Full Text of this article is available as a PDF (763.6 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARQUILLA E. R., FINN J. GENETIC DIFFERENCES IN ANTIBODY PRODUCTION TO DETERMINANT GROUPS ON INSULIN. Science. 1963 Oct 18;142(3590):400–401. doi: 10.1126/science.142.3590.400. [DOI] [PubMed] [Google Scholar]
  2. Ellman L., Green I., Martin W. J., Benacerraf B. Linkage between the poly-L-lysine gene and the locus controlling the major histocompatibility antigens in strain 2 guinea pigs. Proc Natl Acad Sci U S A. 1970 Jun;66(2):322–328. doi: 10.1073/pnas.66.2.322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gasser D. L. Genetic control of the immune response in mice. II. A two-way selection experiment for specific immunologic competence. J Immunol. 1970 Oct;105(4):908–911. [PubMed] [Google Scholar]
  4. Gasser D. L., Silvers W. K. Genetic control of the immune response in mice. 3. An association between H-2 type and reaction to H-Y. J Immunol. 1971 Mar;106(3):875–876. [PubMed] [Google Scholar]
  5. Green I., Inman J. K., Benacerraf B. Genetic control of the immune response of guinea pigs to limiting doses of bovine serum albumin: relationship to the poly-L-lysine gene. Proc Natl Acad Sci U S A. 1970 Aug;66(4):1267–1274. doi: 10.1073/pnas.66.4.1267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Green I., Paul W. E., Benacerraf B. The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs. J Exp Med. 1966 May 1;123(5):859–879. doi: 10.1084/jem.123.5.859. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. JERNE N. K. Immunological speculations. Annu Rev Microbiol. 1960;14:341–358. doi: 10.1146/annurev.mi.14.100160.002013. [DOI] [PubMed] [Google Scholar]
  8. Levine B. B., Vaz N. M. Effect of combinations of inbred strain, antigen, and antigen dose on immune responsiveness and reagin production in the mouse. A potential mouse model for immune aspects of human atopic allergy. Int Arch Allergy Appl Immunol. 1970;39(2-3):156–171. doi: 10.1159/000230343. [DOI] [PubMed] [Google Scholar]
  9. McBride R. A., Schierman L. W. Hapten-carrier relationships of isoantigens. A model for immunological maturation based on the conversion of haptens of carriers by antibody. J Exp Med. 1970 Feb;131(2):377–390. doi: 10.1084/jem.131.2.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. McDevitt H. O., Benacerraf B. Genetic control of specific immune responses. Adv Immunol. 1969;11:31–74. doi: 10.1016/s0065-2776(08)60477-0. [DOI] [PubMed] [Google Scholar]
  11. McDevitt H. O., Chinitz A. Genetic control of the antibody response: relationship between immune response and histocompatibility (H-2) type. Science. 1969 Mar 14;163(3872):1207–1208. doi: 10.1126/science.163.3872.1207. [DOI] [PubMed] [Google Scholar]
  12. McDevitt H. O., Tyan M. L. Genetic control of the antibody response in inbred mice. Transfer of response by spleen cells and linkage to the major histocompatibility (H-2) locus. J Exp Med. 1968 Jul 1;128(1):1–11. [PMC free article] [PubMed] [Google Scholar]
  13. Mitchison N. A. The dosage requirements for immunological paralysis by soluble proteins. Immunology. 1968 Oct;15(4):509–530. [PMC free article] [PubMed] [Google Scholar]
  14. Mozes E., Maron E., Arnon R., Sela M. [Strain-dependent differences in the specificity of antibody responses toward lysozyme]. J Immunol. 1971 Mar;106(3):862–864. [PubMed] [Google Scholar]
  15. Mozes E., McDevitt H. O., Jaton J. C., Sela M. The genetic control of antibody specificity. J Exp Med. 1969 Dec 1;130(6):1263–1278. doi: 10.1084/jem.130.6.1263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mozes E., McDevitt H. O., Jaton J. C., Sela M. The nature of the antigenic determinant in a genetic control of the antibody response. J Exp Med. 1969 Sep 1;130(3):493–504. doi: 10.1084/jem.130.3.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mozes E., Shearer G. M., Sela M. Cellular basis of the genetic control of immune responses to synthetic polypeptides. I. Differences in frequency of splenic precursor cells specific for a synthetic polypeptide derived from multichain polyproline ((T,G)-Pro--L) in high and low responder inbred mouse strains. J Exp Med. 1970 Oct 1;132(4):613–622. doi: 10.1084/jem.132.4.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Pincus C. S., Lamm M. E., Nussenzweig V. Regulation of the immune response: suppressive and enhancing effects of passively administered antibody. J Exp Med. 1971 May 1;133(5):987–1003. doi: 10.1084/jem.133.5.987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rathbun W. E., Hildemann W. H. Genetic control of the antibody response to simple haptens in congenic strains of mice. J Immunol. 1970 Jul;105(1):98–107. [PubMed] [Google Scholar]
  20. STIMPFLING J. H. METHODS FOR DETECTION OF HEMAGGLUTININS IN MOUSE ISOANTISERA. Methods Med Res. 1964;10:22–26. [PubMed] [Google Scholar]
  21. Shearer G. M., Mozes E., Sela M. Cellular basis of the genetic control of immune responses to synthetic polypeptides. II. Frequency of immunocompetent precursors specific for two distinct regions within (Phe, G)-Pro--L, a synthetic polypeptide derived from multichain polyproline, in inbred mouse strains. J Exp Med. 1971 Feb 1;133(2):216–230. doi: 10.1084/jem.133.2.216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Skárová B., Ríha I. Genetic control of the immune response. I. Differences in immune response of inbred strains of mice to p-aminobenzoic acid and sulphanilic acid. Folia Microbiol (Praha) 1969;14(4):364–371. doi: 10.1007/BF02872705. [DOI] [PubMed] [Google Scholar]
  23. Stimpfling J. H., McBroom C. R. The effect of H-2 on the humoral antibody response to a non-H-2 blood group antigen. Transplantation. 1971 Jan;11(1):87–89. doi: 10.1097/00007890-197101000-00012. [DOI] [PubMed] [Google Scholar]
  24. Terres G., Morrison S. L., Habicht G. S. A quantitative difference in the immune response between male and female mice. Proc Soc Exp Biol Med. 1968 Mar;127(3):664–667. doi: 10.3181/00379727-127-32768. [DOI] [PubMed] [Google Scholar]
  25. Vaz N. M., Levine B. B. Immune responses of inbred mice to repeated low doses of antigen: relationship to histocompatibility (H-2) type. Science. 1970 May 15;168(3933):852–854. doi: 10.1126/science.168.3933.852. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES