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. 1971 Oct 31;134(5):1170–1186. doi: 10.1084/jem.134.5.1170

THE PERITONEAL EXUDATE LYMPHOCYTE

I. DIFFERENCES IN ANTIGEN RESPONSIVENESS BETWEEN PERITONEAL EXUDATE AND LYMPH NODE LYMPHOCYTES FROM IMMUNIZED GUINEA PIGS

David L Rosenstreich 1, J Thomas Blake 1, Alan S Rosenthal 1
PMCID: PMC2139018  PMID: 5112203

Abstract

Peritoneal exudate lymphocytes from guinea pigs immunized with horse radish peroxidase, dinitrophenyl guinea pig albumin, or ferritin in complete Freund's adjuvant have been shown to be significantly more reactive than other lymphocytes in two in vitro assays of cellular immune function: production of macrophage migration inhibitory factor and antigen-induced lymphocyte proliferation. The enhanced reactivity of peritoneal exudate lymphocytes cannot be accounted for by artifacts introduced by column purification or by the presence of nonlymphoid accessory cells. These observations suggest that the peritoneal exudate lymphocyte pool is a highly enriched source of cellular immune effector cells with specificity directed towards those antigenic determinants to which an animal has been recently exposed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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