Abstract
Three breeding lines, originating from dogs with SLE, have been established. Two lines were initiated by mating a female with SLE with a normal male. The third line resulted from a mating of two affected dogs. Brother-to-sister matings have reached the third generation in each line. In addition, backcross and outcross matings were carried out. More than one-third of the autopsied dogs had thymic abnormalities. The commonest lesion was a lymphoid follicle; the thymus of one dog contained multiple granulomas, and in one animal a reticulum cell sarcoma of the thymus was found. Multiple serological abnormalities, including positive LE cell tests, anti-nuclear antibodies (ANA), and rheumatoid factor, were found in the progeny. The development of ANA appeared unrelated to the incidence of positive LE cell tests. About 10% of the animals had rheumatoid factor in their serum. Control populations of dogs; including house pets; two other, unrelated lines of inbred dogs; and normal dogs housed in the same facility as the SLE colony did not have these abnormalities. The incidence of positive LE cell tests in the inbred, backcross, and outcross matings was not consistent with any conventional genetic mechanism of inheritance. It is conceivable that the results can be explained by vertical transmission of an infectious agent in a genetically susceptible individual.
Full Text
The Full Text of this article is available as a PDF (1.3 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BURCH P. R., ROWELL N. R. SYSTEMIC LUPUS ERYTHEMATOSUS: ETIOLOGICAL ASPECTS. Am J Med. 1965 May;38:793–801. doi: 10.1016/0002-9343(65)90199-3. [DOI] [PubMed] [Google Scholar]
- Burnet M. The Harben Lectures 1966. Implications for autoimmune disease in man of studies on NZB mice and their hybrids. 2. Renal and thymic disease. R Inst Public Health Hyg J. 1966 May-Jun;29(3):95–103. [PubMed] [Google Scholar]
- DONALDSON L. B., DE ALVAREZ R. R. Further observations on lupus erythematosus associated with pregnancy. Am J Obstet Gynecol. 1962 Jun 1;83:1461–1473. doi: 10.1016/s0002-9378(16)35991-9. [DOI] [PubMed] [Google Scholar]
- Dunn T. B., Deringer M. K. Reticulum cell neoplasm, type B, or the "Hodgkin's-like lesion" of the mouse. J Natl Cancer Inst. 1968 Apr;40(4):771–821. [PubMed] [Google Scholar]
- East J. Immunopathology and neoplasms in New Zealand black (NZB) and SJL-J mice. Prog Exp Tumor Res. 1970;13:84–134. doi: 10.1159/000386038. [DOI] [PubMed] [Google Scholar]
- GALBRAITH R. F., SUMMERSKILL W. H., MURRAY J. SYSTEMIC LUPUS ERYTHEMATOSUS, CIRRHOSIS AND ULCERATIVE COLITIS AFTER THYMECTOMY FOR MYASTHENIA GRAVIS. N Engl J Med. 1964 Jan 30;270:229–231. doi: 10.1056/NEJM196401302700504. [DOI] [PubMed] [Google Scholar]
- HARGRAVES M. M. The L.E. cell phenomenon. Adv Intern Med. 1954;6:133–160. [PubMed] [Google Scholar]
- Johnson J. S., Vaughan J. H., Swisher S. N. Canine immunoglobulins. II. Antibody activities in six immunoglobulin classes. J Immunol. 1967 May;98(5):935–940. [PubMed] [Google Scholar]
- LARSSON O. THYMOMA AND SYSTEMIC LUPUS ERYTHEMATOSUS IN THE SAME PATIENT. Lancet. 1963 Sep 28;2(7309):665–666. doi: 10.1016/s0140-6736(63)90457-4. [DOI] [PubMed] [Google Scholar]
- LEWIS R. M., SCHWARTZ R., HENRY W. B., Jr CANINE SYSTEMIC LUPUS ERYTHEMATOSUS. Blood. 1965 Feb;25:143–160. [PubMed] [Google Scholar]
- Lewis R. M., Borel Y. Canine rheumatoid arthritis; a case report. Arthritis Rheum. 1971 Jan-Feb;14(1):67–74. doi: 10.1002/art.1780140109. [DOI] [PubMed] [Google Scholar]
- Lewis R. M., Schwartz R. S., Gilmore C. E. Autoimmune diseases in domestic animals. Ann N Y Acad Sci. 1965 Jun 30;124(1):178–200. doi: 10.1111/j.1749-6632.1965.tb18956.x. [DOI] [PubMed] [Google Scholar]
- MACKAY I. R., DEGAIL P. THYMIC "GERMINAL CENTRES" AND PLASMA CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS. Lancet. 1963 Sep 28;2(7309):667–667. doi: 10.1016/s0140-6736(63)90458-6. [DOI] [PubMed] [Google Scholar]
- MARSHALL A. H., WHITE R. G. The immunological reactivity of the thymus. Br J Exp Pathol. 1961 Aug;42:379–385. [PMC free article] [PubMed] [Google Scholar]
- MARSHALL A. H., WHITE R. G. The immunological reactivity of the thymus. Br J Exp Pathol. 1961 Aug;42:379–385. [PMC free article] [PubMed] [Google Scholar]
- MUND A., SIMSON J., ROTHFIELD N. Effect of pregnancy on course of systemic lupus erythematosus. JAMA. 1963 Mar 16;183:917–920. doi: 10.1001/jama.1963.03700110049009. [DOI] [PubMed] [Google Scholar]
- SCHEIDEGGER J. J. Une micro-méthode de l'immuno-electrophorèse. Int Arch Allergy Appl Immunol. 1955;7(2):103–110. [PubMed] [Google Scholar]
- SHERMAN J. D., ADNER M. M., DAMESHEK W. DIRECT INJECTION OF THE THYMUS WITH ANTIGENIC SUBSTANCES. Proc Soc Exp Biol Med. 1964 Apr;115:866–870. doi: 10.3181/00379727-115-29059. [DOI] [PubMed] [Google Scholar]
- de Vries M. J., Hijmans W. Pathological changes of thymic epithelial cells and autoimmune disease in NZB, NZW and (NZB x NZW)F1 mice. Immunology. 1967 Feb;12(2):179–196. [PMC free article] [PubMed] [Google Scholar]