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. 1972 Jan 1;135(1):81–97. doi: 10.1084/jem.135.1.81

A PREALBUMIN ACTIVATOR OF PREKALLIKREIN

III. APPEARANCE OF CHEMOTACTIC ACTIVITY FOR HUMAN NEUTROPHILS BY THE CONVERSION OF HUMAN PREKALLIKREIN TO KALLIKREIN

Allen P Kaplan 1, A B Kay 1, K Frank Austen 1
PMCID: PMC2139117  PMID: 5009705

Abstract

Human plasma kallikrein has been shown to directly and selectively attract human neutrophils from a mixed leukocyte population. The capacity of plasma kallikrein to be chemotactic and to generate the nonapeptide bradykinin was maintained during progressive purification. While neither highly purified prekallikrein nor the prealbumin Hageman factor fragments were chemotactic alone, their interaction so as to convert prekallikrein to kallikrein yielded both chemotactic and kinin-generating activity. Both functions of kallikrein were inhibited by treatment with diisopropyl fluorophosphate, indicating an essential role for the active site of the enzyme in the expression of its chemotactic activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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