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. 1972 Feb 29;135(3):516–532. doi: 10.1084/jem.135.3.516

CHRONIC ALLOGENEIC DISEASE

III. GENETIC REQUIREMENTS FOR THE INDUCTION OF GLOMERULONEPHRITIS

Helga Gleichmann 1, Ernst Gleichmann 1, Janine André-Schwartz 1, Robert S Schwartz 1
PMCID: PMC2139130  PMID: 4621662

Abstract

The pathogenesis of glomerulonephritis in F1 hybrid mice injected with parental spleen cells was investigated in several ways. Whenever glomerulonephritis developed, the lesion had the typical morphology produced by antigen-antibody complexes. Experiments employing backcross mice demonstrated that the antigen is supplied by the recipient and that it is specified by the H-2 gene complex, or by a locus closely linked to H-2. The source of the antibody was investigated by staining glomerular lesions with fluorescein isothiocyanate-tagged anti-immunoglobulin allotype sera. Only donor-type allotypes could be detected. The ability of the donor's immunocytes to respond to the recipient's histocompatibility antigens in such a way as to produce nephritogenic immune complexes varied from strain to strain, and seemed to be controlled by a gene unrelated to H-2. The results suggest that cell surface antigens, such as histocompatibility antigens, may be of importance in the pathogenesis of several kinds of glomerulonephritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andres G. A., Accinni L., Hsu K. C., Penn I., Porter K. A., Rendall J. M., Seegal B. C., Starzl T. E. Human renal transplants. 3. Immunopathologic studies. Lab Invest. 1970 Jun;22(6):588–604. [PMC free article] [PubMed] [Google Scholar]
  2. BOYSE E. A., OLD L. J., CHOUROULINKOV I. CYTOTOXIC TEST FOR DEMONSTRATION OF MOUSE ANTIBODY. Methods Med Res. 1964;10:39–47. [PubMed] [Google Scholar]
  3. Billingham R. E. The passenger cell concept in transplantation immunology. Cell Immunol. 1971 Feb;2(1):1–12. doi: 10.1016/0008-8749(71)90022-0. [DOI] [PubMed] [Google Scholar]
  4. Charlton R. K., Zmijewski C. M. Soluble HL-A7 antigen: localization in the beta-lipoprotein fraction of human serum. Science. 1970 Nov 6;170(3958):636–637. doi: 10.1126/science.170.3958.636. [DOI] [PubMed] [Google Scholar]
  5. Churg J., Habib R., White R. H. Pathology of the nephrotic syndrome in children: a report for the International Study of Kidney Disease in Children. Lancet. 1970 Jun 20;760(1):1299–1302. doi: 10.1016/s0140-6736(70)91905-7. [DOI] [PubMed] [Google Scholar]
  6. Cudkowicz G. Genetic control of bone marrow graft rejection. I. Determinant-specific difference of reactivity in two pairs of inbred mouse strains. J Exp Med. 1971 Jul 1;134(1):281–293. doi: 10.1084/jem.134.1.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Edgington T. S., Glassock R. J., Dixon F. J. Autologous immune complex nephritis induced with renal tubular antigen. I. Identification and isolation of the pathogenetic antigen. J Exp Med. 1968 Mar 1;127(3):555–572. doi: 10.1084/jem.127.3.555. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Haughton G., McGehee M. P. Cytolysis of mouse lymph node cells by alloantibody: a comparison of guinea-pig and rabbit complements. Immunology. 1969 Apr;16(4):447–461. [PMC free article] [PubMed] [Google Scholar]
  9. Klein J., Shreffler D. C. The H-2 model for the major histocompatibility systems. Transplant Rev. 1971;6:3–29. doi: 10.1111/j.1600-065x.1971.tb00457.x. [DOI] [PubMed] [Google Scholar]
  10. Lewis M. G., Loughridge L. W., Phillips T. M. Immunological studies in nephrotic syndrome associated with extrarenal malignant disease. Lancet. 1971 Jul 17;2(7716):134–135. doi: 10.1016/s0140-6736(71)92305-1. [DOI] [PubMed] [Google Scholar]
  11. Lewis R. M., Armstrong M. Y., André-Schwartz J., Muftuoglu A., Beldotti L., Schwartz R. S. Chronic allogeneic disease. I. Development of glomerulonephritis. J Exp Med. 1968 Oct 1;128(4):653–679. doi: 10.1084/jem.128.4.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Patel R., Mickey M. R., Terasaki P. I. Leucocyte antigens and disease. I. Association of HL-A2 and chronic glomerulonephritis. Br Med J. 1969 May 17;2(5654):424–426. doi: 10.1136/bmj.2.5654.424. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Plager J., Stutzman L. Acute nephrotic syndrome as a manifestation of active Hodgkin's Disease. Report of four cases and review of the literature. Am J Med. 1971 Jan;50(1):56–66. doi: 10.1016/0002-9343(71)90205-1. [DOI] [PubMed] [Google Scholar]
  14. Sjögren H. O., Hellström I., Bansal S. C., Hellström K. E. Suggestive evidence that the "blocking antibodies" of tumor-bearing individuals may be antigen--antibody complexes. Proc Natl Acad Sci U S A. 1971 Jun;68(6):1372–1375. doi: 10.1073/pnas.68.6.1372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Stimpfling J. H., Reichert A. E. Strain C57BL-10ScSn and its congenic resistant sublines. Transplant Proc. 1970 Mar;2(1):39–47. [PubMed] [Google Scholar]

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