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. 1972 Feb 29;135(3):660–674. doi: 10.1084/jem.135.3.660

RECEPTORS ON IMMUNOCOMPETENT CELLS

V. CELLULAR CORRELATES OF THE "MATURATION" OF THE IMMUNE RESPONSE

Joseph M Davie 1, William E Paul 1
PMCID: PMC2139136  PMID: 5061979

Abstract

During the course of the immune response to dinitrophenylated guinea pig albumin (DNP-GPA), a striking and parallel increase in avidity for ε-DNP-L-lysine occurs in the receptors on antigen-binding lymphocytes, antibody secreted by individual plaque-forming cells, and serum antibody molecules. A detailed analysis of the avidity distribution of antibody produced by plaque-forming cells indicates that this "immunologic maturation" is primarily due to a preservation of the high avidity subpopulation and a striking loss in the low avidity population rather than to sequential appearance of these cells. Moreover, the demonstration of the increased avidity of receptors of antigen-binding lymphocytes, which appear to be precursors of antibody-synthesizing cells, strongly suggests that the antigen-driven selectional process operates primarily on this cell type.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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