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. 1972 Mar 31;135(4):793–807. doi: 10.1084/jem.135.4.793

MORPHOLOGICAL AND FUNCTIONAL STUDIES OF FETAL THYMUS TRANSPLANTS IN MICE

W D Biggar 1, Osias Stutman 1, Robert A Good 1
PMCID: PMC2139150  PMID: 5018052

Abstract

The fetal thymus at 13 days of gestation withstands transplantation and develops normally under the renal capsule of a syngenic host. Distinct differences were observed between the fetal thymus grafts and grafts from neonatal or adult thymus donors. The fetal thymus graft did not undergo the rapid and severe necrosis observed when adult thymus was grafted. Furthermore, when thymuses were transplanted into allogenic recipients, rejection was delayed. The fetal thymus was as effective as the adult thymus in restoring syngenic neonatally thymectomized mice and far superior to adult thymus when grafted into allogenic recipients. These observations seem relevant to clinical efforts to restore immunocompetence in patients with congenital absence of the thymus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. August C. S., Rosen F. S., Filler R. M., Janeway C. A., Markowski B., Kay H. E. Implantation of a foetal thymus, restoring immunological competence in a patient with thymic aplasia (Digeorge's syndrome). Lancet. 1968 Dec 7;2(7580):1210–1211. doi: 10.1016/s0140-6736(68)91693-0. [DOI] [PubMed] [Google Scholar]
  2. Blackburn W. R., Miller J. F. Electron microscopic studies of thymus graft regeneration and rejection. 3. Allogeneic grafts. Lab Invest. 1968 Jun;18(6):771–781. [PubMed] [Google Scholar]
  3. Blackburn W. R., Miller J. F. Electron microscopic studies of thymus graft regeneration and rejection. II. Syngeneic-irradiated grafts. Lab Invest. 1967 Jun;16(6):833–846. [PubMed] [Google Scholar]
  4. Cleveland W. W., Fogel B. J., Brown W. T., Kay H. E. Foetal thymic transplant in a case of Digeorge's syndrome. Lancet. 1968 Dec 7;2(7580):1211–1214. doi: 10.1016/s0140-6736(68)91694-2. [DOI] [PubMed] [Google Scholar]
  5. Dempster W. J. Transplanting the thymus. Lancet. 1969 Mar 1;1(7592):468–468. doi: 10.1016/s0140-6736(69)91511-6. [DOI] [PubMed] [Google Scholar]
  6. Dempster W. J. Treatment of congenital thymic aplasia by graft of fetal thymus. Lancet. 1970 Jun 13;1(7659):1294–1295. doi: 10.1016/s0140-6736(70)91775-7. [DOI] [PubMed] [Google Scholar]
  7. Dukor P., Miller J. F., House W., Allman V. Regeneration of thymus grafts. I. Histological and cytological aspects. Transplantation. 1965 Sep;3(5):639–668. doi: 10.1097/00007890-196509000-00006. [DOI] [PubMed] [Google Scholar]
  8. GREEN I. THE REGENERATION OF F1 HOST CELL SPLEEN AND THYMUS AT ECTOPIC SITES IN F1 ANIMALS INDUCED BY IMPLANTATION OF PARENTAL SPLEEN AND THYMUS. J Exp Med. 1964 Apr 1;119:581–592. doi: 10.1084/jem.119.4.581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jaffe H. L. AUTOPLASTIC THYMUS TRANSPLANTS : II. WITH PARTICULAR REFERENCE TO THE REGENERATION OF THE RETICULUM CELLS AND THE FORMATION OF HASSALL'S CORPUSCLES. J Exp Med. 1926 Sep 30;44(4):523–532. doi: 10.1084/jem.44.4.523. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LAW L. W., MILLER J. H. The influence of thymectomy on the incidence of carcinogen-induced leukemia in strain DBA mice. J Natl Cancer Inst. 1950 Oct;11(2):425–437. [PubMed] [Google Scholar]
  11. MARTINEZ C., SMITH J. M., AUST J. B., GOOD R. A. Acquired tolerance to skin homografts in mice of different strains. Proc Soc Exp Biol Med. 1958 Apr;97(4):736–738. doi: 10.3181/00379727-97-23863. [DOI] [PubMed] [Google Scholar]
  12. METCALF D., WAKONIG-VAARTAJA R. STEM CELL REPLACEMENT IN NORMAL THYMUS GRAFTS. Proc Soc Exp Biol Med. 1964 Mar;115:731–735. doi: 10.3181/00379727-115-29022. [DOI] [PubMed] [Google Scholar]
  13. Owen J. J., Raff M. C. Studies on the differentiation of thymus-derived lymphocytes. J Exp Med. 1970 Dec 1;132(6):1216–1232. doi: 10.1084/jem.132.6.1216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. SCHLESINGER M. SEROLOGIC STUDIES OF EMBRYONIC AND TROPHOBLASTIC TISSUES OF THE MOUSE. J Immunol. 1964 Aug;93:255–263. [PubMed] [Google Scholar]
  15. SJODIN K., DALMASSO A. P., SMITH J. M., MARTINEZ C. THYMECTOMY IN NEWBORN AND ADULT MICE. Transplantation. 1963 Oct;1:521–525. doi: 10.1097/00007890-196301040-00011. [DOI] [PubMed] [Google Scholar]
  16. Schlesinger M., Hurvitz D. Serological analysis of thymus and spleen grafts. J Exp Med. 1968 Jun 1;127(6):1127–1137. doi: 10.1084/jem.127.6.1127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stutman O., Good R. A. Immunocompetence of embryonic hemopoietic cells after traffic to thymus. Transplant Proc. 1971 Mar;3(1):923–925. [PubMed] [Google Scholar]
  18. Stutman O., Yunis E. J., Good R. A. Tolerance induction with thymus grafts in neonatally thymectomized mice. J Immunol. 1969 Jul;103(1):92–99. [PubMed] [Google Scholar]
  19. Stutman O., Yunis E. J., Teague P. O., Good R. A. Graft-versus-host reactions induced by transplantation of parental strain thymus in neonatally thymectomized F1 hybrid mice. Transplantation. 1968 Jul;6(4):514–523. doi: 10.1097/00007890-196807000-00002. [DOI] [PubMed] [Google Scholar]

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