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. 1972 Oct 1;136(4):663–675. doi: 10.1084/jem.136.4.663

SURFACE ANTIGENS OF IMMUNOCOMPETENT CELLS

III. IN VITRO STUDIES OF THE ROLE OF B AND T CELLS IN IMMUNOLOGICAL MEMORY

J J Mond 1, T Takahashi 1, G J Thorbecke 1
PMCID: PMC2139273  PMID: 4560343

Abstract

The effect of preincubation with anti-θ or anti-mouse immunoglobulin (Ig) and complement (C') on immune responsiveness of spleen cells from BALB/c mice immunized with sheep erythrocytes (SE) was investigated. Both treatments greatly depressed the remaining ability to produce a secondary response to SE in vitro. Normal BALB/c spleen cells were far less effective in reconstituting the responses of such depleted cell populations than were much smaller numbers of untreated immune spleen cells. Thymus-derived cell (T cell) memory appeared early after immunization and showed specificity for the immunizing antigens. Recombination of anti-Ig-treated with anti-θ-treated immune spleen cells resulted in virtually complete reconstitution of responsiveness. The presence of immunological memory in T cells and the nature of their surface receptors are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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